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HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance.
Cells
December 2024
Department of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Human immunodeficiency virus type-1 (HIV-1) associated comorbidities account for the majority of poor health outcomes in people living with HIV (PLWH) in the era of antiretroviral therapy. Lung-related comorbidities such as chronic obstructive pulmonary disease (COPD) and bacterial pneumonia are primarily responsible for increased morbidity and mortality in PLWH, even when compensated for smoking. Smokers and COPD patients demonstrate cilia shortening, attenuated ciliary beat frequency (CBF), dysfunctional ciliated cells along with goblet cell hyperplasia, and mucus hypersecretion.
View Article and Find Full Text PDFScreening and Studying of Blood miRNAs as Potential Diagnostic Markers for Papillary Thyroid Carcinoma.
Onco Targets Ther
December 2024
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Jinan, 250012, People's Republic of China.
Objective: MiRNAs play a pivotal role in tumorigenesis and development by exerting negative regulation on the expression of target genes. In this study, bioinformatics techniques and online database were employed to investigate the specific miRNA-target gene regulatory network in PTC, which was subsequently validated using human blood samples and compared to existing tumor markers.
Methods: The miRNA (GSE50901) and Gene Expression (GSE113629) chip screening data of human PTC tissues were retrieved from GEO database.
Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17.
Curr Med Sci
December 2024
Department of Clinical Basis of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Objective: The objective of this study was to explore the therapeutic effects of kaempferol (Kae) on rheumatoid arthritis (RA) and to elucidate the underlying mechanisms.
Methods: The collagen-induced arthritis (CIA) model was established using collagen II to induce RA. Mice were treated with Kae at a dose of 25 or 50 mg/kg/day via gavage.
MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients.
J Inflamm Res
December 2024
Department of Emergency Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
Article Synopsis
- The study explores the role of extracellular vesicles (EVs) in the communication between plasma and immune cells during sepsis, aiming to identify biomarkers linked to organ dysfunction and patient prognosis.
- Researchers isolated PMN-derived EVs from septic shock patients and healthy controls, conducting miRNA sequencing and bioinformatics analysis to identify significant differences.
- Findings revealed specific miRNAs and PMN-related proteins that could serve as biomarkers for sepsis-related organ dysfunction, and the study identified potential prognostic predictors while also highlighting how plasma-EVs impact neutrophil autophagy.
Nanosphere hydrogel-mediated delivery of miR-34a-5p improves achilles tendon function in rat model.
Injury
December 2024
Department of Hand Surgery, Affiliated Hospital of Nantong University, Nantong 226001, PR China. Electronic address:
Restoring motor function and preventing re-rupture and adhesion during Achilles tendon healing remain significant clinical challenges. Increasing evidence suggests that miRNA plays a crucial role in tendon healing and regeneration. The previously designed nanosphere hydrogel sustained-release system enables targeted, controlled release of drugs.
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