Empirical evidence proves that the antioxidant property plays a main role in the biological activities of biomaterials, which is influenced by several factors. In order to explore in-depth, the influence of ionic systems on the antioxidant activity of collagen peptides was studied. Type-I-collagen peptides (GBB-10SP and TYPE-S) contained a high amount of hydrophobic amino acids and possessed good antioxidant activity at high concentrations in water. On the other hand, increasing [H ] and [Na ] concentrations (0.1 M to 0.5 M) decreased the reducing power of GBB-10SP and TYPE-S; however, [Ca ] had no effect on the reducing power. Interestingly, the hydroxyl radical scavenging rate of these two peptides was increased by [Na ], decreased by [H ], and [Ca ] had no effect. In general, TYPE-S showed better antioxidant properties than GBB-10SP. Overall, the above results confirmed that the antioxidant capacity of collagen peptides was affected by [H ] and [Na ] and not by [Ca ]. PRACTICAL APPLICATIONS: The present study mainly deals with the influence of ions on the antioxidant properties of collagen peptides. Recently, fish collagen peptides have been widely used as food supplements to cure several disorders and maintain normal physiological health in humans. It is noted that the use of collagen from fish processing wastes has brought several potential benefits including low value-added products, preventing environmental pollution, and disease transmission by mammalian-based collagen. But the biological activity of this peptide varied based on the preparation and its biochemical compositions. Here, we are reporting how to improve the biological activity of collagen, and also the factors affecting the antioxidant properties in order to avoid the down-regulating mechanism. This study concluded that the [H ] and [Na ] influenced the antioxidant properties of collagen peptides, but [Ca ] had not effect on the antioxidant properties.
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