Distance association models constitute a useful tool for the analysis and graphical representation of cross-classified data in which distances between points inversely describe the association between two categorical variables. When the number of cells is large and the data counts result in sparse tables, the combination of clustering and representation reduces the number of parameters to be estimated and facilitates interpretation. In this article, a latent block distance-association model is proposed to apply block clustering to the outcomes of two categorical variables while the cluster centers are represented in a low dimensional space in terms of a distance-association model. This model is particularly useful for contingency tables in which both the rows and the columns are characterized as profiles of sets of response variables. The parameters are estimated under a Poisson sampling scheme using a generalized EM algorithm. The performance of the model is tested in a Monte Carlo experiment, and an empirical data set is analyzed to illustrate the model.
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http://dx.doi.org/10.1080/00273171.2019.1634995 | DOI Listing |
Stat Med
November 2023
Department of Statistics and O.R., University of Granada, Granada, Spain.
Biometrical sciences and disease diagnosis in particular, are often concerned with the analysis of associations for cross-classified data, for which distance association models give us a graphical interpretation for non-sparse matrices with a low number of categories. In this framework, usually binary exploratory and response variables are present, with analysis based on individual profiles being of great interest. For saturated models, we show the usual linear relationship for log-linear models is preserved in full dimension for the distance association parameterization.
View Article and Find Full Text PDFPLoS One
December 2022
State Key Laboratory of Public Big Data, College of Computer Science and Technology, Guizhou University, Guiyang, China.
Multivariate Behav Res
January 2021
Methodology and Statistics Unit, Institute of Psychology, Leiden University.
Distance association models constitute a useful tool for the analysis and graphical representation of cross-classified data in which distances between points inversely describe the association between two categorical variables. When the number of cells is large and the data counts result in sparse tables, the combination of clustering and representation reduces the number of parameters to be estimated and facilitates interpretation. In this article, a latent block distance-association model is proposed to apply block clustering to the outcomes of two categorical variables while the cluster centers are represented in a low dimensional space in terms of a distance-association model.
View Article and Find Full Text PDFNat Struct Mol Biol
September 2015
Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
The bacterial alarmone 5-aminoimidazole-4-carboxamide riboside 5'-triphosphate (AICAR triphosphate or ZTP), derived from the monophosphorylated purine precursor ZMP, accumulates during folate starvation. ZTP regulates genes involved in purine and folate metabolism through a cognate riboswitch. The linker connecting this riboswitch's two subdomains varies in length by over 100 nucleotides.
View Article and Find Full Text PDFPLoS One
January 2016
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America.
Probabilistic association discovery aims at identifying the association between random vectors, regardless of number of variables involved or linear/nonlinear functional forms. Recently, applications in high-dimensional data have generated rising interest in probabilistic association discovery. We developed a framework based on functions on the observation graph, named MeDiA (Mean Distance Association).
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