AI Article Synopsis
- Silver nanoparticles (AgNPs) are used in various products for their ability to fight pathogens, but their safety and effects on body tissues are still debated.
- This study focused on how AgNPs affect the production and composition of basement membranes and integrin interactions in lung, esophageal, breast, and colorectal epithelial cells.
- Using multiple scientific techniques, the research found that AgNP exposure disrupts cell adhesion and basement membrane dynamics, revealing potential mechanisms for how they may negatively impact epithelial health.
Article Abstract
Silver nanoparticles (AgNPs) are widely used in consumer and pharmaceutical products due to their antipathogenic properties. However, safety concerns have been raised due to their bioactive properties. While reports have demonstrated AgNPs can embed within the extracellular matrix, their effects on basement membrane (BM) production, integrin engagement, and tissue-integrity are not well-defined. This study analyzed the effects of AgNPs on BM production, composition and integrin/focal adhesion interactions in representative lung, esophageal, breast and colorectal epithelia models. A multidisciplinary approach including focused proteomics, QPCR arrays, pathway analyses, and immune-based, structural and functional assays was used to identify molecular and physiological changes in cell adhesions and the BM induced by acute and chronic AgNP exposure. Dysregulated targets included CD44 and transforming growth factor-beta, two proteins frequently altered during pathogenesis. Results indicate AgNP exposure interferes with BM and cell adhesion dynamics, and provide insight into the mechanisms of AgNP-induced disruption of epithelial physiology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814557 | PMC |
| http://dx.doi.org/10.1016/j.nano.2019.102070 | DOI Listing |
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