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High-performance thin-layer chromatography-umu combined with nontarget analysis-a sensitive genotoxicity screening tool applicable for potable water analysis.
Environ Toxicol Chem
January 2025
Zweckverband Landeswasserversorgung, Laboratory for Operation Control and Research, Langenau, Germany.
Monitoring of genotoxic chemicals released into the water cycle or formed through transformation processes is critical to prevent harm to human health. The development of the high-performance thin-layer chromatography (HPTLC)-umu bioassay combines sample separation and detection of genotoxic substances in the low ng/L concentration range. In this study, raw, process, and drinking water samples from 11 different waterworks in Germany were analyzed using the HPTLC-umu.
View Article and Find Full Text PDFThe Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage.
Medicina (Kaunas)
December 2024
Department of Internal Medicine, Division of Endocrinology, University Hospital Centre Zagreb, Croatian Referral Center for Obesity Treatment, Kišpatićeva 12, 10000 Zagreb, Croatia.
The prevalence of metabolic syndrome (MetS) worldwide is rapid and significant on a global scale. A 2022 meta-analysis of data from 28 million individuals revealed a global prevalence of 45.1%, with notably higher rates in the Eastern Mediterranean Region and the Americas, particularly in high-income countries.
View Article and Find Full Text PDFMicronuclei as genotoxicity endpoint applied in the co-culture of two mammalian cell lines.
Mutat Res Genet Toxicol Environ Mutagen
January 2025
Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Strasse 9, 97078 Würzburg, Germany. Electronic address:
There has been a shift from traditional animal models towards alternative methods. While 2D cell culture has a decade long tradition, more advances methods like 3D cultures, organoids, and co-culture techniques, which better mimic in vivo conditions, are not yet well established in every research area. Genotoxicity assessment is an integral part of toxicological testing or regulatory approval of pharmaceuticals and chemicals.
View Article and Find Full Text PDFCytogenetic markers in newborns of mothers with comorbidities.
Mutat Res Genet Toxicol Environ Mutagen
January 2025
Health Promotion Program University of Franca, SP, Brazil. Electronic address:
We have studied the presence and frequency of micronuclei in exfoliated oral mucosa cells of full-term newborns and their association with maternal prenatal factors. We report an analytical, observational, cross-sectional, prospective study that includes 97 preterm infants (<37 weeks), 37 newborns from mothers with comorbidities, and 60 newborns from mothers without comorbidities, in a tertiary public hospital. Oral mucosa cells were collected within 24 h after birth.
View Article and Find Full Text PDFCytotoxicity and genotoxicity of zinc oxide nanoparticles in human peripheral blood mononuclear cells.
Mutat Res Genet Toxicol Environ Mutagen
January 2025
Universidad del Cauca, Facultad de Ciencias de la Salud, Departamento de Patología, Grupo de investigación en Inmunología y Enfermedades Infecciosas, Popayán (Cauca), Colombia. Electronic address:
Zinc oxide nanoparticles (ZnO-NPs) are of interest in biomedical applications, environmental remediation, and agriculture. ZnO-NPs inhibit the growth of phytopathogenic fungi and bacteria. We have evaluated their effects on mitochondrial function and the induction of membrane damage, apoptosis, and DNA damage in human peripheral blood mononuclear cells (PBMC) in vitro.
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