AI Article Synopsis
Article Abstract
The antimicrobial activity represents a cornerstone in the development of biomaterials: it is a leading request in many areas, including biology, medicine, environment and industry. Over the years, different polymeric scaffolds are proposed as solutions, based on the encapsulation of metal ions/particles, antibacterial agents or antibiotics. However, the compliance with the biocompatibility criteria and the concentration of the active principles to avoid under- and over-dosing are being debated. In this work, we propose the synthesis of a versatile hydrogel using branched polyacrylic acid (carbomer 974P) and aliphatic polyetherdiamine (elastamine®) through physico-chemical transition, able to show its ability to counteract the bacterial growth and infections thanks to the polymers used, that are not subjected to further chemical modifications. In particular, the antimicrobial activity is clearly demonstrated against Staphyloccoccus aureus and Candida albicans, two well-known opportunistic pathogens. Moreover, we discuss the hydrogel use as drug carrier to design a unique device able to combine the antibacterial/antimicrobial properties to the controlled drug delivery, as a promising tool for a wide range of biomedical applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.msec.2019.109791 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Shear stress controls prokaryotic and eukaryotic biofilm communities together with EPS and metabolomic expression in a semi-controlled coastal environment in the NW Mediterranean Sea.
Environ Microbiome
December 2024
Laboratoire MAPIEM, Université de Toulon, Toulon, France.
While waves, swells and currents are important drivers of the ocean, their specific influence on the biocolonization of marine surfaces has been little studied. The aim of this study was to determine how hydrodynamics influence the dynamics of microbial communities, metabolic production, macrofoulers and the associated vagile fauna. Using a field device simulating a shear stress gradient, a multi-scale characterization of attached communities (metabarcoding, LC-MS, biochemical tests, microscopy) was carried out for one month each season in Toulon Bay (northwestern Mediterranean).
View Article and Find Full Text PDFSynthetic Aggregates and Bituminous Materials Based on Industrial Waste.
Materials (Basel)
December 2024
National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Str., 400293 Cluj-Napoca, Romania.
The transition to a circular economy requires new materials and products with new production designs, technologies, and processes. In order to create new materials with physico-chemical qualities suitable for application in the building materials engineering sector, stone dust and polymer waste-two environmentally hazardous industrial wastes-were combined in this study. The materials obtained were evaluated based on an analysis performed using the Micro-Deval test.
View Article and Find Full Text PDFForced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells.
Int J Mol Sci
November 2024
World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
The metabolism of zinc and manganese plays a pivotal role in cancer progression by mediating cancer cell growth and metastasis. The SLC30A family proteins and mediate the efflux of zinc, manganese, and probably other transition element ions outside the cytoplasm to the extracellular space or into intracellular membrane compartments. The SLC39A family members and are their functional antagonists that transfer these ions into the cytoplasm.
View Article and Find Full Text PDFThe Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.
Bull Exp Biol Med
November 2024
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Article Synopsis
- The study measured the electrical impedance and pulsation ranges of brachial and femoral arteries in rats after 14 days of hindlimb unloading (a model for microgravity).
- Results showed that the femoral artery constricted while the brachial artery dilated, with both exhibiting reduced pulsation dynamics.
- The ability of the femoral artery to switch to an active pulsatile mode during bloodletting was significantly lower in unloaded rats than in control rats, indicating potential negative effects of microgravity on blood circulation.
Insight into physico-chemical properties of oxalatoborate-based ionic liquids through combined experimental-theoretical characterization.
Phys Chem Chem Phys
November 2024
Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Ionic liquids (ILs) including oxalatoborate anions, like bis(oxalato)borate (BOB) and difluoro(oxalato)borate (DFOB) are extensively used in the battery sector as additives to promote the formation of protective layers on the surface of high-voltage cathode materials. In this work four ILs have been synthesized: -ethoxyethyl--methylpiperidinium bis(oxalato)borate (PIPBOB), -ethoxyethyl--methylpiperidinium difluoro(oxalato)borate (PIPDFOB), -propyl--methylpiperidinium bis(oxalato)borate (PIPBOB) and -propyl--methylpiperidinium difluoro(oxalato)borate (PIPDFOB) and their thermal properties have been linked to their structure. The presence of an oxygen atom in the PIP lateral chain suppresses crystallization of the ILs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!