Garcia-Campos et al. describe MAZTER-seq, which deploys a sequence-specific, methylation-sensitive bacterial single-stranded ribonuclease MazF to provide nucleotide-resolution quantification of mA methylation sites. The study reveals many new sites and supports the idea of a predictable "mA code," where methylation levels are dictated primarily by local sequence at the site of methylation.
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| http://dx.doi.org/10.1016/j.cell.2019.07.006 | DOI Listing |
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