Polypeptide nanoparticles were obtained by the miniemulsion polymerization of -(-nitrobenzyl)-l-cysteine (NBC) -carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.
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| http://dx.doi.org/10.1021/jacs.9b06750 | DOI Listing |
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