Evaluating Antineoplastic Agents and Occupational Exposures Among Italian Workers Using SIREP Surveillance System.

J Occup Environ Med

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL), Rome (Mr Scarselli, Mr Di Marzio, Dr Iavicoli); Department of Prevention, Occupational Health and Safety (SPeSAL), Local Health Authority of Bari, Bari (Dr Corfiati), Italy.

Published: August 2019

Objective: The aim of the study is to evaluate exposures to antineoplastic agents at workplaces in healthcare and manufacturing in Italy.

Methods: Data on antineoplastic agents were collected from occupational exposure registries. Statistical analysis was carried out for exposure-related variables. The number of workers potentially exposed was estimated for selected industrial sectors. Concurrent exposures were investigated using cluster analysis.

Results: Overall 15,763 exposure situations were analyzed during 1996 to 2016. Most exposures occurred in healthcare (66%). A total of 11,830 workers potentially exposed to antineoplastic agents was estimated. Concurrent exposures were frequently detected in the pharmaceutical industry and among healthcare workers.

Conclusions: Occupational exposure to antineoplastic agents currently represents a matter of concern both in the chemical industry and in the healthcare sector. The growing number of agents in use supports the need to constantly control exposures.

Download full-text PDF

Source
http://dx.doi.org/10.1097/JOM.0000000000001641DOI Listing

Publication Analysis

Top Keywords

antineoplastic agents
20
occupational exposure
8
workers exposed
8
concurrent exposures
8
industry healthcare
8
agents
6
exposures
6
evaluating antineoplastic
4
agents occupational
4
occupational exposures
4

Similar Publications

The impact of antioxidant-ciprofloxacin combinations on the evolution of antibiotic resistance in Pseudomonas aeruginosa biofilms.

NPJ Biofilms Microbiomes

December 2024

Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, 2200, Denmark.

The evolution of antimicrobial resistance (AMR) in biofilms, driven by mechanisms like oxidative stress, is a major challenge. This study investigates whether antioxidants (AOs) such as N-acetyl-cysteine (NAC) and Edaravone (ED) can reduce AMR in Pseudomonas aeruginosa biofilms exposed to sub-inhibitory concentrations of ciprofloxacin (CIP). In vitro experimental evolution studies were conducted using flow cells and glass beads biofilm models.

View Article and Find Full Text PDF

Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota.

Nat Commun

December 2024

AZTI, Marine Research, Basque Research and Technology Alliance (BRTA), Sukarrieta, Spain.

Marine brown algae produce the highly recalcitrant polysaccharide fucoidan, contributing to long-term oceanic carbon storage and climate regulation. Fucoidan is degraded by specialized heterotrophic bacteria, which promote ecosystem function and global carbon turnover using largely uncharacterized mechanisms. Here, we isolate and study two Planctomycetota strains from the microbiome associated with the alga Fucus spiralis, which grow efficiently on chemically diverse fucoidans.

View Article and Find Full Text PDF

Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a strategy for boosting immune response against diverse types of tumors. To induce pyroptosis, we utilize designed tightly regulated gasdermin D variants comprising different pore-forming capabilities and diverse modes of activation, representing a toolbox of ICD inducers.

View Article and Find Full Text PDF

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane.

View Article and Find Full Text PDF

Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. We examine 6 cohorts including 25 ICI-induced SJS/TEN patients and conduct single-cell RNA sequencing (scRNA-seq) analysis, which shows overexpression of macrophage-derived CXCL10 that recruits CXCR3 cytotoxic T lymphocytes (CTL) in blister cells from ICI-SJS/TEN skin lesions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!