The hypokinetic effect on the nystagmic reaction and illusory sensations upon caloric and galvanic stimulations of the labyrinths was studied on six test subjects (professional gymnasts). Under normal conditions the sportsmen predominantly showed the nystagmic response to the caloric irritation of the left labyrinth. A 10-day hypokinetic exposure produced a noticeable decrease of the above asymmetric nystagmic reaction to the caloric irritation of both labyrinths. Simultaneously an enhancement of illusory sensations and a decrease of their thresholds in response to the firect current labyrinthine stimulation were noted. The above changes can be attributed to the hypokinesia-induced decline of mechanisms of vestibular adaptation of sportsmen.
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PLoS One
June 2018
Department of Internal Medicine, Rehabilitation Hospital, School of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
Introduction: The vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects.
Material And Methods: Forty-eight young healthy male volunteers were examined under basal conditions and at various times after reaching the maximal nystagmic reaction following air caloric vestibular test.
Aviakosm Ekolog Med
November 2011
The article presents the results of oculomotor reaction investigations during 24-hour sleep deprivation of 10 normal male subjects aged 25 to 30 yrs. Video nistagmograph VNG System VO-25 was used for binocular registration of eye movements. The proposed video procedures for assessment of the functional ability of human operator are a balancing test, investigation of saccadic and smooth tracking eye movements.
View Article and Find Full Text PDFPrzegl Lek
September 2005
Specjalistyczne Centrum, Diagnostyczno-Zabiegowe Medicina, Kraków.
Caloric stimulation is one of few clinically proven tests assessing the function of each vestibule separately in neonates. Its results represent the continuity of vestibulo-ocular reflex, beginning in the lateral vestibular canal. Vestibular disorders are diagnosed in 20 to even 70% neonates with sensorineural hearing loss with the prevalence of individuals with profound and acquired deafness.
View Article and Find Full Text PDFOtol Neurotol
May 2005
Unit of Neuro-Otology, ENT Department, G. Papanikolaou Hospital, Thessaloniki, Greece.
Hypothesis And Background: Experimental evidence suggests that steroids as well as various neurotransmitters are critically involved in the functioning of the vestibular system in health and disease. Yet there are no pertinent human data. We hypothesized that changes in the serum levels of cortisol and plasma levels of excitatory and inhibitory neurotransmitters may occur during evoked vertigo.
View Article and Find Full Text PDFArzneimittelforschung
September 2002
HPR-Human Pharmacodynamic Research, Schaffer & Seibel GmbH, Munich, Germany.
It is known that sedation by H1 antihistaminic drugs can be reduced or avoided if slow release formulations are used for their administration, probably because of a slower increase of the drug concentration in plasma and brain. The aim of this study was to compare two different formulations of dimenhydrinate (CAS 523-87-5), a single fast release tablet with three chewing gums (divided dose principle), with regard to their efficacy in a motion sickness model and their detrimental effect on vigilance and central nervous system (CNS) performance. Caloric stimulation of the eardrum (air at 44 degrees C) was used to induce the symptoms of motion sickness in 24 symptomatic volunteers in a three-way cross-over design comparing three chewing gums (Superpep forte, chewed for 30 min each) containing 20 mg dimenthydrinate each with a 50 mg dimenhydrinate tablet and placebo.
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