AI Article Synopsis
- The study aimed to investigate how systemic inflammation from periodontal disease affects cognitive impairment and dementia.
- Researchers conducted a case and control study with a total of 302 participants, assessing periodontal health, cognitive impairment, and levels of inflammation through 29 biomarkers.
- The results showed some inflammatory markers linked to cognitive impairment in severe periodontitis cases, but unexpectedly, cases with cognitive impairment had lower inflammation levels compared to cognitively healthy individuals, suggesting inflammation may not significantly contribute to cognitive decline.
Article Abstract
Objectives: The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment.
Methods: We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques.
Results: At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding.
Conclusions: Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.
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| http://dx.doi.org/10.1111/ger.12431 | DOI Listing |
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