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Public Health.
Alzheimers Dement
December 2024
Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Background: Recent research on preventing cognitive decline has focused on lifestyle interventions, with first studies indicating cognitive benefits and suggesting a positive link between adherence to the interventions and their effectiveness. The purpose of this study was to analyse possible predictors of this very adherence to single components of a multi-domain lifestyle intervention.
Methods: A total of n = 317 participants of the intervention group were included, characterized with an age ≥60 (mean age 68.
Public Health.
Alzheimers Dement
December 2024
Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Background: Dementia prevalence is projected to treble worldwide by 2040 highlighting the critical need for effective primary dementia prevention strategies. Initiatives to shape health behaviours/beliefs in childhood increase likelihood of engagement in healthy lifestyle behaviours during adulthood however some subgroups of children are more vulnerable to poor brain health during ageing. Therefore, children must have opportunities to learn about how they can engage in behaviours to improve cardiovascular and psychological health that will protect their brain as they age, contributing to dementia risk reduction (DRR) in later life.
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Alzheimers Dement
December 2024
Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: Malnutrition is a condition associated with negative outcomes in elderly patients, such as loss of functionality and mortality. The cause of malnutrition is multifactorial: secondary to changes in eating habits, dysphagia and loss of interest in food. It is a frequent condition in patients with advanced dementia.
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Alzheimers Dement
December 2024
Unit Cognitive Impairment and Dementia Prevention, Peruvian Institute of Neurosciences, Lima, Peru, Lima, Lima, Peru.
Background: Dementia has sparked interest in identifying modifiable risk factors. It has been proposed that the number of teeth could play a crucial role in cognitive decline, suggesting possible mechanisms such as nutritional influence, inflammation, and neuronal feedback.
Methods: We performed a systematic literature search in January 2024 in PubMed, Scopus and Embase to search observational studies that reported the association between number of teeth and dementia or cognitive decline.
Biomarkers.
Alzheimers Dement
December 2024
Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Background: Plasma amyloid-beta (Aβ) 42/40 ratio and phosphorylated tau 181 (pTau181) are promising blood biomarkers for AD. Compared to heterogenous clinical phenotypes, they are more objective and proximal to the pathological hallmarks of Aβ plaques and tau tangles. Biomarker-guided clustering using Aβ42/40 and pTau181 can potentially establish subpopulations that share similar mechanisms of AD and treatment responses.
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