[This corrects the article DOI: 10.1186/s12014-019-9246-0.].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636090 | PMC |
| http://dx.doi.org/10.1186/s12014-019-9250-4 | DOI Listing |
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RNA-binding proteins are essential for gene regulation and the spatial organization of cells. Here, we report that the yeast ribosome biogenesis factor Loc1p is an intrinsically disordered RNA-binding protein with eight repeating positively charged, unstructured nucleic acid binding (PUN) motifs. While a single of these previously undefined motifs stabilizes folded RNAs, multiple copies strongly cooperate to catalyze RNA folding.
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