The effect of rickettsial antigen-specific T cell line on macrophages infected with Rickettsia tsutsugamushi was studied. It was suggested that the T cells could produce a factor which acts cytotoxically and selectively on infected macrophages.
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http://dx.doi.org/10.1111/j.1348-0421.1988.tb01403.x | DOI Listing |
Pathogens
August 2021
Department of Entomology, USAMD-AFRIMS, Bangkok 10330, Thailand.
Recently, an intradermal inoculation of the rhesus macaque model of scrub typhus has been characterized at our institution. The current project was to establish a rhesus macaque model of scrub typhus using the naturally infected chigger challenge method that faithfully mimics the natural route of pathogen transmission to fully understand the host-pathogen-vector interactions influencing pathogen transmission. Unlike the needle-based inoculation route, -infected chiggers introduce both pathogen and chigger saliva into the host epidermis at the bite site.
View Article and Find Full Text PDFInfect Immun
February 2019
Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University (CVM-KSU), Manhattan, Kansas, USA
Rocky Mountain spotted fever (RMSF) is a potentially fatal tick-borne disease in people and dogs. RMSF is reported in the United States and several countries in North, Central, and South America. The causative agent of this disease, , is transmitted by several species of ticks, including , , and RMSF clinical signs generally include fever, headache, nausea, vomiting, muscle pain, lack of appetite, and rash.
View Article and Find Full Text PDFJ Virol
July 2017
University of Pittsburgh Center for Vaccine Research, Pittsburgh, Pennsylvania, USA
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne RNA virus that causes low mortality but high morbidity rates in humans. In addition to natural outbreaks, there is the potential for exposure to VEEV via aerosolized virus particles. There are currently no FDA-licensed vaccines or antiviral therapies for VEEV.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
April 2015
Centers for Disease Control and Prevention, Rickettsial Zoonoses Branch, 1600 Clifton Rd, MS G13, Atlanta, GA 30333, USA. Electronic address:
Coxiella burnetii, a Gram-negative intracellular bacterium, can give rise to Q fever in humans and is transmitted mainly by inhalation of infected aerosols from animal reservoirs. Serology is commonly used to diagnose Q fever, but the early cellular immune response-i.e.
View Article and Find Full Text PDFVaccine
February 2015
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da-Jie Street, Fengtai, Beijing 100071, China. Electronic address:
Background: Two surface proteins of Rickettsia rickettsii, outer membrane protein B (OmpB) and adhesion 2 (Adr2), have been recognized as protective antigens. Herein, the immunization with both OmpB and Adr2 was performed in mice so as to explore whether their combination could induce an enhanced immunoprotection against R. rickettsii infection.
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