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Efficacy and safety of botulinum toxin injection in the management of chronic symptomatic anal fissure: a systematic review and meta-analysis of randomized controlled trials.
Tech Coloproctol
January 2025
Royal Glamorgan Hospital, Llantrisant, Wales, UK.
Background: Anal fissure is one of the most painful anal conditions. Various management options are available, including topical nitrites, calcium channel blockers, botulinum toxin injection, and lateral internal sphincterotomy. This study aimed to assess the efficacy and safety of botulinum toxin A (BT) injection for the management of symptomatic chronic anal fissures by conducting a systematic review of the literature and meta-analysis of published randomized controlled trials (RCTs).
View Article and Find Full Text PDFThe use of a methylene blue and glyceryl trinitrate-based cream for the treatment of chronic anal fissures: a phase II randomized pilot trial from a referral coloproctological unit.
Tech Coloproctol
January 2025
Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Section of Surgery, General Surgery Unit - Hospital University of Bari, Piazza Giulio Cesare 11, 70124, Bari, SE, Italy.
Background: Chronic anal fissures (CAFs) are the second most common anorectal disease. Non-surgical treatment includes several options with controversial efficacy. The aim of this study was to evaluate the efficacy and safety of a new ointment based on methylene blue in addition to glyceryl trinitrate.
View Article and Find Full Text PDFChili pepper consumption and duration of fissure symptoms onset are associated with perianal fistula development among patients with anal fissure: a case-control study.
BMC Nutr
December 2024
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Perianal fistula is one of the complications of deepened anal fissure. The present case-control study aimed to assess the risk factors of fissure-associated fistulas due to the limited available evidence.
Methods: Patients with fissure-associated fistulas were considered as case, and patients with anal fissure who were undergoing medical treatment without any previous anorectal surgeries were considered as control group.
Decoding the Risks of Fecal Incontinence: A Comprehensive Analysis of Closed Internal Sphincterotomy in Chronic Anal Fissure.
Cureus
November 2024
General Surgery, Lady Reading Hospital Medical Teaching Institution (MTI), Peshawar, PAK.
Introduction An anal fissure is marked by a longitudinal tear in the mucosal lining of the lower anal canal, causing painful defecation and mild anal bleeding. The classical triad includes an anal ulcer, a sentinel tag, and a hypertrophic papilla. This study investigates the frequency of fecal incontinence in patients with anal fissure undergoing closed internal sphincterotomy, offering recent insights for treatment recommendations.
View Article and Find Full Text PDF[Several problems needing attention in the diagnosis and treatment of common perianal benign diseases].
Zhonghua Wei Chang Wai Ke Za Zhi
December 2024
the 989th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army / Research Institute of Anorectal Surgery of the Chinese People's Liberation Army, Luoyang471000, China.
Hemorrhoids, anal fissure, anal fistula and perianal abscess are the most common benign diseases around the anus, which obviously affect people's life and work, and need to be well diagnosed and treated. Based on damage control, the treatment principle is to eliminate relevant disease symptoms and protect the anal function at the same time. Perianal benign diseases are common and frequently occurring, which can be diagnosed and treated in many non-specialist hospitals.
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