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Detection and phylogenetic analysis of blood-associated pathogens from spleen samples of wild raccoons (Procyon lotor) in Germany.
Sci Rep
December 2024
Department of Zoology, Musée National d'Histoire Naturelle, Luxembourg, Luxembourg.
Raccoons (Procyon lotor) originated in North America and have been introduced to Europe. Due to their close contact with human settlements, they are important reservoirs for zoonotic pathogens, such as Baylisascaris procyonis. The relevance and prevalence of vector-borne pathogens have not yet been fully elucidated.
View Article and Find Full Text PDFAchieving malaria-free: Egypt's journey to WHO certification and global implications for disease control.
Trop Med Health
December 2024
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Egypt's recent malaria-free certification by the World Health Organization (WHO) marks a significant achievement in public health, underscoring the effectiveness of sustained national efforts in disease eradication. This milestone, achieved after nearly a century of strategic intervention, highlights the importance of integrated public health programmes and cross-sector collaboration. Egypt's journey involved early initiatives to reduce human-mosquito contact, the establishment of malaria control stations, and comprehensive outbreak management strategies.
View Article and Find Full Text PDFDeep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain?
Algorithms
December 2023
Fetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
In drug-resistant epilepsy, a visual inspection of intracranial electroencephalography (iEEG) signals is often needed to localize the epileptogenic zone (EZ) and guide neurosurgery. The visual assessment of iEEG time-frequency (TF) images is an alternative to signal inspection, but subtle variations may escape the human eye. Here, we propose a deep learning-based metric of visual complexity to interpret TF images extracted from iEEG data and aim to assess its ability to identify the EZ in the brain.
View Article and Find Full Text PDFEffect of a spatial repellent on malaria incidence in an area of western Kenya characterised by high malaria transmission, insecticide resistance, and universal coverage of insecticide treated nets (part of the AEGIS Consortium): a cluster-randomised, controlled trial.
Lancet
December 2024
Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
Background: Spatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human-vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial repellent epidemiological efficacy against Aedes-borne viruses but inconclusive outcomes against malaria.
View Article and Find Full Text PDFLeucinostatins target Plasmodium mitochondria to block malaria transmission.
Parasit Vectors
December 2024
Department of Biological Sciences, Florida International University, 11200 SW 8th St, Miami, FL, 33199, USA.
Background: Malaria remains a critical disease. Leucinostatins from the fungus Purpureocillium lilacinum inhibited the transmission of Plasmodium falciparum to mosquitoes via contact.
Methods: Here, we modified the leucinostatin B (LB) C-terminus to make derivatives and examined their inhibition against malaria transmission to mosquitoes.
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