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Bioactive Lactones from the Mangrove-Derived Fungus sp. TGM112. | LitMetric

Bioactive Lactones from the Mangrove-Derived Fungus sp. TGM112.

Mar Drugs

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.

Published: July 2019

AI Article Synopsis

  • Three new lactones, penicilactones A-C, were isolated from the mangrove fungus sp. TGM112.
  • Their structures and configurations were analyzed using NMR, MS, ECD, and CD spectroscopic techniques.
  • One compound exhibited antibacterial properties with an MIC of 6.25 μg/mL, and another showed insecticidal effects against larvae with an LC of 78.5 μg/mL.

Article Abstract

Three new lactones penicilactones A-C (-) were obtained from the mangrove-derived fungus sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(OAc)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound showed antibacterial activity against with an MIC value of 6.25 μg/mL. Compound showed insecticidal activity against newly hatched larvae of with the LC value of 78.5 (±0.58) μg/mL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722761PMC
http://dx.doi.org/10.3390/md17080433DOI Listing

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