AI Article Synopsis
- Wound healing involves multiple steps, and effective materials must combat infections from bacteria.
- Curcumin offers strong antimicrobial, anti-inflammatory, and antioxidant benefits, while titanium dioxide (TiO) is safe for biomedical use.
- By combining curcumin with TiO nanoparticles and integrating them into a poly vinyl alcohol (PVA) and sodium alginate (SA) patch, researchers demonstrated improved antibacterial activity and wound healing in studies with Wister rats, suggesting it may be a great option for wound dressings.
Article Abstract
Wound healing is a complex multistep process. Wound healing materials should have good antibacterial activity against wound infection causing microbes. Curcumin has effective antimicrobial activity, anti-inflammatory and antioxidant property. Titanium dioxide (TiO) is a biocompatible, nontoxic material used for many biomedical applications. The Usage of curcumin tagged TiO nanoparticles for wound healing activity is promising due to the properties of both curcumin and TiO. We have synthesized curcumin tagged TiO nanoparticles. The synthesized materials are characterized with XRD, FTIR and TEM. TiO-Cur nanocomposite was incorporated into poly vinyl alcohol (PVA) and sodium alginate (SA) patch. The PVA/SA/TiO-Cur patch was prepared by gel casting method. Antibacterial efficiency of PVA/SA/TiO-Cur patch was analyzed. Further, in vivo studies conducted on Wister rats confirmed the enhanced wound healing property of the PVA/SA/TiO-Cur patch. Our results suggest that this could be an ideal biomaterial for wound dressing applications.
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| http://dx.doi.org/10.1016/j.ijbiomac.2019.07.125 | DOI Listing |
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