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Symptom improvement and predictors associated with improvement after 6 weeks of alpha-blocker therapy: An exploratory, single-arm, open-label cohort study. | LitMetric

AI Article Synopsis

  • The study aimed to determine how many patients benefit from alpha-blocker therapy and to identify characteristics of those who improve.
  • Conducted as a 6-week observational study in 22 pharmacies in the Netherlands, it included patients with new prescriptions for alpha-blockers.
  • Results showed that 37% of patients felt better after treatment, with improvement linked to continued use of the medication, but no definitive predictors for symptom improvement were found, suggesting trial-based prescribing is still necessary.

Article Abstract

Objectives: Clinicians should not only know how many patients will benefit from alpha-blocker therapy but should also be able to identify who will benefit. We studied the changes in patient symptoms following alpha-blocker therapy and the predictors of symptom improvement in clinical practice.

Design: This was a single-arm, open-label observational cohort study with a 6-week follow-up.

Setting: Twenty-two pharmacies in the Netherlands.

Participants: Patients were eligible for inclusion if they attended a pharmacy with a new prescription for an alpha-blocker from a general practitioner or urologist.

Primary And Secondary Outcomes: Outcomes were assessed using the International Prostate Symptom Score (IPSS), Overactive Bladder Questionnaire Short Form (OAB-q SF), and Patient Global Impression of Improvement (PGI-I). Demographic, disease-related, and drug-related information were collected to identify predictors of symptom improvement. These predictors were then assessed by logistic and linear regression analyses of both the original data set and an imputed data set that accounted for the missing variables.

Results: During the study, 37% of patients with lower urinary tract symptoms perceived clear symptomatic improvement based on the results of the PGI-I. Improvement was more likely in those who still used alpha-blockers at the end of the 6-week study period and in those who used multiple medications. Although symptom scores decreased significantly on the IPSS and OAB-q SF, the only predictor of change was the pretreatment symptom severity.

Conclusions: Approximately one-third of our cohort perceived symptom improvement on alpha-blocker therapy. However, we identified no clear predictors of who might benefit from alpha-blocker treatment, indicating that alpha-blockers should still be prescribed on a trial basis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657904PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220417PLOS

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