Nano-titanium dioxide is a kind of widely used nanomaterial that exhibits various adverse outcomes. However, the role of oxidative stress in this regard remains controversial. This study aimed to evaluate whether oxidative stress is one of the toxicity mechanisms induced by nano-titanium dioxide in rats and mice model. In this meta-analysis, 64 relevant publications were included through detailed database search. The pooled results showed that nano-titanium dioxide exposure could promote the expression of oxidants, such as malonaldehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), superoxide anion (O), and hydrogen peroxide (HO). Meanwhile, the levels of antioxidant-related enzymes and molecules, such as superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT), were reduced. Subgroup analysis revealed that different intervention routes, exposure periods, exposure dosages, and sample sources could affect the oxidative stress when exposed to nano-titanium dioxide. It was worth noting that the levels of MDA, 8-OHdG, and GSH significantly increased (P < 0.05) when the particle size of nano-titanium dioxide was < 10 nm, whereas HO, SOD, and GPx showed the highest effect at 10-40 nm. This study indicated that nano-titanium dioxide could cause oxidative damage by affecting the levels of enzymes and molecules involved in oxidative stress in rats and mice. And these results could provide a reference for studies of the toxicity mechanism induced by nano-titanium dioxide in the future.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-01761-zDOI Listing

Publication Analysis

Top Keywords

nano-titanium dioxide
32
oxidative stress
16
induced nano-titanium
12
rats mice
12
oxidative damage
8
nano-titanium
8
dioxide
8
dioxide rats
8
enzymes molecules
8
oxidative
6

Similar Publications

Application of Nano-Titanium Dioxide in Food Antibacterial Packaging Materials.

Bioengineering (Basel)

December 2024

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Quality & Safety in Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.

Food waste and food safety issues caused by food spoilage have been brought into focus. The inhibition of food spoilage bacteria growth is the key to maintaining food quality and extending the shelf life of food. Photodynamic inactivation (PDI) is an efficient antibacterial strategy which provides a new idea for the antibacterial preservation of food.

View Article and Find Full Text PDF

Perfluorooctanoate and nano-titanium dioxide modulate male gonadal function in the mussel Mytilus coruscus.

Aquat Toxicol

January 2025

International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, PR China. Electronic address:

Perfluorooctanoic acid (PFOA) and nano-titanium dioxide (nano-TiO₂) are widely used in industrial applications such as manufacturing and textiles, and can be released into the environment, causing toxicity to marine organisms. To study the effects of these pollutants on the gonadal development, we exposed the males of Mytilus coruscus to varying PFOA concentrations (2 and 200 μg/L) alone or combined with nano-TiO (0.1 mg/L, size: 25 nm) for 14 days.

View Article and Find Full Text PDF

Engineered nanomaterials (ENM) are capable of crossing the placental barrier and accumulating in fetal tissue. Specifically, the ENM nano-titanium dioxide (nano-TiO), has been shown to accumulate in placental and fetal tissue, resulting in decreased birthweight in pups. Additionally, nano-TiO is an established cardiac toxicant and regulator of glucose homeostasis, and exposure in utero may lead to serious maladaptive responses in cardiac development and overall metabolism.

View Article and Find Full Text PDF

Nano-TiO impairs the health of crabs Charybdis japonica under warming conditions through waterborne and dietary exposures.

J Hazard Mater

January 2025

International Research Center for Marine Biosciences, Shanghai Ocean University, Ministry of Science and Technology, College of Fisheries and Life Science, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

The widespread use of nano titanium dioxide (nano-TiO₂) poses ecological risks to marine ecosystems, especially when combined with ocean warming. However, most previous studies have only examined water-related exposures, leaving a gap in research on the impact of food transfer on organisms. In this work, the harmful impacts of nano-TiO on the Japanese swimming crab Charybdis japonica were studied through three scenarios: direct exposure (DE) of the crabs to warming and nano-TiO, indirect exposure (IE) via consumption of thick-shelled mussels Mytilus coruscus exposed to the same conditions, and combined exposure (CE), where crabs were directly subjected to warming and nano-TiO while feeding affected mussels.

View Article and Find Full Text PDF

Effects of perfluorooctanoic acid and nano titanium dioxide on the immune response and energy allocation in Mytilus coruscus.

Chemosphere

February 2025

International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai, 201306, China. Electronic address:

Perfluorooctanoic acid (PFOA) functions as a surfactant, while nano-titanium dioxide (nano-TiO) serves as an antibacterial agent. These substances are extensively utilized in industrial production and, upon release into aquatic environments, pose significant threats to the viability and development of marine organisms. However, research into the effects of PFOA and nano-TiO on the immune functions and cellular energy allocation (CEA) of bivalves remains limited.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!