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| http://dx.doi.org/10.1016/j.hrcr.2019.04.005 | DOI Listing |
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Expedited loading with intravenous sotalol is safe and feasible-primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry.
Heart Rhythm
July 2024
Division of Cardiovascular Medicine, University of Utah Health, Salt Lake City, Utah.
Article Synopsis
- A study evaluated the use of intravenous (IV) sotalol for safely and quickly loading patients with atrial fibrillation, contrasting it with the traditional oral loading process that often requires a 3-day hospital stay.
- The research involved 167 patients, mainly older adults, and found that 99% were admitted for sotalol initiation, achieving a short average hospital stay of 1.1 days with few adverse effects.
- Results suggest that IV sotalol is a safe and efficient alternative for treating atrial arrhythmias; however, more research is necessary to determine the optimal hospital monitoring duration.
Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions.
Environ Sci Pollut Res Int
March 2024
AdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.
Article Synopsis
- Wastewater-based epidemiology (WBE) is assessed for its reliability in estimating pharmaceutical consumption by comparing it to actual prescription data in urban areas.
- Most pharmaceuticals, like ciprofloxacin and metoprolol, showed a minimal difference (below 0.2 order of magnitude) between WBE estimates and control values, indicating good reliability, especially for sedatives.
- Seasonal patterns affected the load of specific drugs in the sewer system, but these changes did not significantly impact the reliability of WBE, suggesting it is a valid tool for estimating drug consumption despite some areas needing further research.
Protocol Development and Initial Experience With Intravenous Sotalol Loading for Atrial Arrhythmias.
Crit Pathw Cardiol
March 2023
Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.
Background: Oral sotalol is a class III antiarrhythmic commonly used for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). Recently, the Food and Drug Administration (FDA) approved the use of IV sotalol loading, based primarily on modeling data for the infusion. We aimed to describe a protocol and experience with IV sotalol loading for elective treatment of adult patients with AF and atrial flutter (AFL).
View Article and Find Full Text PDFImplementation of an intravenous sotalol initiation protocol: Implications for feasibility, safety, and length of stay.
J Cardiovasc Electrophysiol
March 2023
Division of Cardiology, Northwestern University, Chicago, Illinois, USA.
Introduction: Oral sotalol initiation requires a multiple-day, inpatient admission to monitor for QT prolongation during loading. A 1-day intravenous (IV) sotalol loading protocol was approved by the United States Food and Drug Administration in March 2020, but limited data on clinical use and administration currently exists. This study describes implementation of an IV sotalol protocol within an integrated health system, provides initial efficacy and safety outcomes, and examines length of stay (LOS) compared with oral sotalol initiation.
View Article and Find Full Text PDFEvaluation of a program for outpatient sotalol loading with physician and pharmacist monitoring.
J Am Pharm Assoc (2003)
September 2022
Background: Dose-dependent QT prolongation with class III antiarrhythmics mandates close monitoring often in an inpatient setting. Outpatient sotalol loading monitor provides an alternative to patients that is cost effective and allows preservation of hospital resources.
Objectives: The objectives for this study include assessing adverse events, assessing patient adherence to monitoring and follow-up, comparing hospital cost and resource utilization, and evaluating patient satisfaction with outpatient sotalol loading program.
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