AI Article Synopsis
- This study aimed to evaluate how well patients with type 2 diabetes adhere to oral antidiabetic drugs (OADs) and explore the connection between drug adherence and glycaemic control while considering other influencing factors.
- It involved analyzing data from 5,457 patients at a large hospital in Saudi Arabia in 2016, revealing that 48.6% had good adherence to medication, particularly those using specific drugs like repaglinide and pioglitazone.
- The study highlighted that women had poorer adherence compared to men, and certain factors like hyperpolypharmacy and being non-Saudi increased the likelihood of medication oversupply, although no link was found between adherence and glycaemic control.
Article Abstract
Objectives: The purpose of this study is to measure the adherence rates of oral antidiabetic drugs (OADs) in patients with type 2 diabetes mellitus (T2DM) and assess the relationship of glycaemic control and adherence to OADs after controlling for other associated factors.
Design: Cross-sectional retrospective study.
Setting: Large tertiary hospital in the central region of Saudi Arabia.
Participants: 5457patients aged 18 years and older diagnosed with T2DM during the period from 1 January 2016 to 31 December 2016.
Primary And Secondary Outcome Measures: The modified medication possession ratio (mMPR) was calculated as a proxy measure for adherence of OADs. The factors associated with OADs non-adherence and medication oversupply were assessed using multinomial logistic regression models. The secondary outcomes were to measure the association between OADs adherence and glycaemic control.
Results: Majority of patients with T2DM were females (n=3400, 62.3%). The average glycated haemoglobin was 8.2±1.67. Among the study population, 48.6% had good adherence (mMPR >0.8) and 8.6% had a medication oversupply (mMPR >1.2). Good adherence was highest among those using repaglinide (71.0%) followed by pioglitazone (65.0%) and sitagliptin (59.0%). In the multivariate analysis, women with T2DM were more likely to have poor adherence (adjusted OR (AOR)=0.76, 95% CI=0.67, 0.86) compared with men. Also, medication oversupply was more likely among patients with hyperpolypharmacy (AOR=1.88, 95% CI=1.36, 2.63), comorbid osteoarthritis (AOR=1.72, 95% CI=1.20, 02.45) and non-Saudi patients (AOR=1.53, 95% CI=1.16, 2.01). However, no association was found between glycaemic control and adherence to OADs.
Conclusion: The study findings support the growing concern of non-adherence to OADs among patients with T2DM in Saudi Arabia. Decision makers have to invest in behavioural interventions that will boost medication adherence rates. This is particularly important in patients with polypharmacy and high burden of comorbid conditions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661664 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2019-029280 | DOI Listing |
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