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Evaluation of current patient-based real-time quality control in clinical chemistry testing.
Clin Chim Acta
December 2024
Department of Clinical Chemistry, Department of Biochemistry, University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye.
Introduction: To perform simulation studies on patient-based real-time quality control (PBRTQC) for aspartate aminotransferase (AST), iron (Fe), potassium (K), and thyrotropin (thyroid stimulating hormone, TSH) analytes, focusing on optimizing systematic error detection while minimizing data loss.
Methods: Clinical laboratory data for the four analytes were analyzed using various truncation methods. Among these methods, truncation limits corresponding to fixed percentiles (e.
A Two-Way Mendelian Randomization Analysis on the Link between Thyroid Activity Function and Coronary Atherosclerosis.
Rev Cardiovasc Med
December 2024
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, China.
Article Synopsis
- The study investigates how thyroid hormones may contribute to coronary atherosclerosis, a leading cause of coronary artery disease (CAD).
- Utilizing large genetic databases, the research examines various thyroid-related disorders and their potential links to coronary atherosclerosis through Mendelian Randomization techniques.
- Results indicate that conditions like hypothyroidism and Graves' disease increase the risk of coronary atherosclerosis, while no causal relationship was found between certain thyroid hormones (FT4 and TSH) and the disease.
Efficacy and safety of Danggui Liuhuang Decoction combined with antithyroid drugs for hyperthyroidism: A systematic review and meta-analysis.
J Ethnopharmacol
December 2024
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. Electronic address:
Ethnopharmacological Relevance: Hyperthyroidism is a prevalent clinical endocrine disorder. Danggui Liuhuang Decoction (DGLHD), a traditional Chinese herbal medicine formula, has shown potential benefits for patients with hyperthyroidism in recent studies. However, the clinical efficacy and safety of DGLHD have not been systematically evaluated.
View Article and Find Full Text PDFInterleukin-6 and thyroid-stimulating hormone index predict plaque stability in carotid artery stenosis: analyses by lasso-logistic regression.
Front Cardiovasc Med
December 2024
Department of Vascular Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Objective: To develop and validate a new prediction model based on the Lass-logistic regression with inflammatory serologic markers for the assessment of carotid plaque stability, providing clinicians with a reliable tool for risk stratification and decision-making in the management of carotid artery disease.
Methods: In this study, we retrospectively collected the data of the patients who underwent carotid endarterectomy (CEA) from 2019 to 2023 in Nanjing Drum Tower Hospital. Demographic characteristics, vascular risk factors, and the results of preoperative serum biochemistry were measured and collected.
Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.
PLoS One
December 2024
Department of Ophthalmology and Visual Science, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Thyroid-associated ophthalmopathy (TAO), an autoimmune disorder of the retrobulbar tissue, is present in up to 50 percent of Graves's hyperthyroidism patients. Insulin-like growth factor 1 receptor (IGF-1R) has received attention as a target for the development of therapeutic agent for TAO. IGF-1R and TSHR (thyroid stimulating hormone receptor) interact with each other to form a physical or functional complex, further promoting the development of TAO.
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