Objective: This study was conducted to demonstrate the temporal trends in perinatal outcomes of triplet pregnancies over the last two decades.
Methods: The medical records of patients with triplet pregnancies at two Korean tertiary-care hospitals from 1992 to 2012 were retrospectively reviewed in regard to maternal and neonatal outcomes. The study was divided into two periods for analysis: period I (1992-2001) and period II (2003-2012).
Results: Over a 21-year period, 65 women with triplet pregnancies and 185 neonates were analyzed. Period II, when compared with period I, was associated with improved maternal outcomes, characterized by a decreased incidence of preeclampsia (31.8% vs. 2.3%, =0.002) and anemia (68.2% vs. 30.2%, =0.003) during pregnancy. Regarding neonatal aspects, the composite morbidity of period II was significantly decreased compared with that of period I, as assessed with a generalized estimating equation for logistic regression (26.2% vs. 8.1%, =0.03). Multivariable analysis revealed that the gestational age at delivery and the period were significantly associated with the composite neonatal morbidity (<0.001 and 0.007, respectively).
Conclusion: Improved neonatal morbidity was associated with a higher gestational age at delivery and with the more recent decade.
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| http://dx.doi.org/10.5468/ogs.2019.62.4.224 | DOI Listing |
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