High-functioning autism spectrum disorders represent an important differential diagnosis not only in pediatric but also in adult psychiatry as well as psychotherapy. Although the topic is getting increasing attention, especially in science, it has still barely arrived in everyday clinical life of psychiatric-psychotherapeutic care.
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Stigma by association revealed in a survey conducted among UNAFAM members.
Encephale
March 2025
Hôpitaux pédiatriques de Nice, CHU Lenval, 57, avenue de la Californie, 06200 Nice, France.
Background: Stigma by association (also known as secondary, family, or courtesy stigma) adds to public stigma and self-stigma. First described by Erwin Goffman in 1963, it affects those close to stigmatized individuals, particularly people with mental health conditions. King et al.
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Wolfson Centre for Young People's Mental Health, Cardiff University; Centre for Neuropsychiatric Genetics and Genomics, Cardiff University. Electronic address:
Background: There is clinical interest in recognising copy number variants (CNVs) in children as many have immediate and long-term health implications. Neurodevelopmental CNVs are associated with intellectual disability, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), conditions typically diagnosed by medical practitioners. However, neurodevelopmental CNVs may have additional, early developmental impacts that have yet to be examined in unselected populations.
View Article and Find Full Text PDFEffects of pharmacological inhibition of FABP4 during gestation and lactation on offspring neurodevelopment and behavior.
Neurosci Lett
March 2025
Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
Fatty acid-binding protein 4 (FABP4), a key regulator of lipid metabolism and inflammation, has been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). This study investigated the effects of FABP4 inhibition during gestation and lactation on offspring neurodevelopment using the selective FABP4 inhibitor BMS309403. Female mice received BMS309403 (15 mg/kg) via oral gavage from two weeks before mating to postnatal day 28 (P28).
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Curr Opin Neurobiol
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Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan. Electronic address:
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments and restricted, repetitive behaviors. ASD exhibits a strong genetic basis, with rare and common genetic variants contributing to its etiology. Copy number variations (CNVs), deletions or duplications of chromosomal segments, have emerged as key contributors to ASD risk.
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March 2025
University of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA 19104, United States of America.
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