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Age-Related Decline of Retinal Oxygen Extraction in Healthy Subjects. | LitMetric

AI Article Synopsis

  • The study aimed to explore how total retinal blood flow and oxygen extraction change with age in healthy individuals and their relationship with structural OCT measures.
  • It involved 68 participants, measuring retinal blood flow, oxygen saturation, nerve fiber thickness, and estimating retinal ganglion cell numbers, revealing a decline in both structural and vascular parameters with increasing age.
  • The strongest correlation found was between total retinal oxygen extraction and the number of retinal ganglion cells, highlighting the need for more longitudinal studies to understand vascular and neuronal changes over time.

Article Abstract

Purpose: To investigate the age-dependence of total retinal blood flow and total retinal oxygen extraction in healthy subjects and determine their possible correlations with structural optical coherence tomography (OCT) parameters.

Methods: This observational cross-sectional study consisted of 68 healthy subjects (mean ± SD age, 45.6 ± 16.3 years; 47% female). Total retinal oxygen extraction was calculated based on measurement of total retinal blood flow using bi-directional Doppler OCT and measurement of oxygen saturation using spectroscopic reflectometry. Retinal nerve fiber layer thickness was measured using OCT, and the total number of retinal ganglion cells was estimated based on a previous published model. Correlation of these parameters with age was studied and the association between structural OCT parameters and hemodynamic vascular parameters was calculated.

Results: Both structural and vascular parameters showed a significant decline with increasing age. The correlation coefficients were between r = -0.25 and r = -0.41. Furthermore, structural and vascular parameters were significantly correlated with each other. The strongest association was found between the level of total retinal oxygen extraction and the number of retinal ganglion cells (r = 0.75, P < 0.001).

Conclusions: We showed that there was an age-related decline of retinal oxygen extraction. Levels of retinal oxygen extraction are correlated to retinal nerve fiber layer thickness and number of retinal ganglion cells. Our data partially explain the wide inter-individual variability in retinal blood flow values in healthy subjects. Longitudinal studies are required to study the time course of vascular and neuronal loss in humans.

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Source
http://dx.doi.org/10.1167/iovs.18-26234DOI Listing

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