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[Analysis of curative effect of orbital apex syndrome caused by sinus disease].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
August 2024
To compare the efficacy of endoscopic sinus surgery and conservative treatment for orbital apex syndrome caused by sinus lesions. The clinical data of 56 patients with orbital apex syndrome caused by sinus lesions who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2018 to August 2023 were retrospectively analyzed and divided into a surgical group of 21 cases and a conservative group of 35 cases. The clinical features and prognosis of the two groups were compared.
View Article and Find Full Text PDFActivation of the inflammasome and pyroptosis cascade in podocytes of patients with minimal change disease.
Clin Kidney J
August 2024
Department of Anatomy, Showa University School of Medicine, Tokyo, Japan.
Background: In contrast to childhood minimal change disease (MCD), adult-onset MCD frequently recurs and requires prolonged immunosuppressive therapy. Accordingly, an investigation of the pathogenesis of adult MCD is required. MCD is usually accompanied by severe dyslipidaemia.
View Article and Find Full Text PDFThe Immunosuppressive Drug LF15-0195 Acts Also on Glomerular Lesions, by a Change in Cytoskeleton Distribution in Podocyte.
Am J Nephrol
October 2024
Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, CHU Nantes, Nantes Université, INSERM, Nantes, France.
Article Synopsis
- - Buffalo/Mna rats develop nephrotic syndrome that can recur after kidney transplantation, and the drug LF15-0195 may help treat both the initial syndrome and post-transplantation issues by promoting regulatory T cells.
- - The study used various techniques to analyze kidney samples from Buff/Mna rats at different disease stages, showing that LF15-0195 treatment restored the foot process architecture of podocytes, which could correlate with reduced proteinuria.
- - Although LF15-0195 didn't significantly change the mRNA or protein levels of several specific podocyte proteins, it improved their distribution within the glomeruli, indicating that the drug might work through immune modulation and potentially also improve the cytoskeleton of endothelial cells under stress
A rare sight: Childhood blepharochalasis presenting as recurrent eyelid swelling: A case report.
Int J Surg Case Rep
August 2024
King Edward Medica University, Lahore 54000, Punjab, Pakistan. Electronic address:
Article Synopsis
- Blepharochalasis is a rare eyelid condition causing painless swelling, usually of the upper eyelids, which can be challenging to diagnose and often requires surgical treatment rather than medication.
- A case study of a 12-year-old highlights recurrent eyelid swelling over six years, eventually diagnosed as blepharochalasis and treated with blepharoplasty.
- Accurate diagnosis is crucial, as blepharochalasis can be mistaken for other conditions like nephrotic syndrome, emphasizing the need for careful clinical evaluation.
A Case Report on Primary Collapsing Glomerulopathy in a Filipino Post-partum Female and An Updated Review of Literature.
Acta Med Philipp
February 2024
Division of Nephrology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila.
Article Synopsis
- - Collapsing Glomerulopathy (CG) is a rare kidney disease that often leads to nephrotic syndrome and can progress rapidly; it has been linked to HIV and is now observed in some COVID-19 patients.
- - A 36-year-old Filipino female presented with severe swelling and kidney issues after giving birth, with various tests ruling out infections and showing signs of kidney damage, leading to a delayed biopsy.
- - The kidney biopsy ultimately confirmed CG, and after initial treatment with tacrolimus, her condition improved, showing no signs of kidney dysfunction during follow-up.
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