3D printing in medicine

2365-6271512019Jul223D printing in medicine3D Print MedNovel design and development of a 3D-printed conformal superficial brachytherapy device for the treatment of non-melanoma skin cancer and keloids.10101010.1186/s41205-019-0045-zSkin tumors are the most predominant form of cancer in the United States. Radiation therapy, particularly high dose-rate (HDR) brachytherapy, provides an effective form of cancer control when surgery is not possible or when surgical margins are incomplete. The treatment of superficial skin cancers on irregular surfaces, such as the nose, lips or ears, present challenges for treatment. To address this issue, we designed and constructed a novel conformal superficial brachytherapy (CSBT) device prototype to improve patient-specific treatment for complex sites. The device is mounted on an automated remote after-loader, providing limited radiation exposure to operating personnel, is inexpensive to construct, and offers a unique method of conformal surface radiation therapy.A prototype of the CSBT device was successfully manufactured. A computed tomography (CT) scan of a Rando phantom was used to plan the target treatment area. The CSBT device has a hexagonal lattice array of retractable rods with radioactive seeds placed at the tip of each rod. A 3D-printed conformal shape insert with a hexagonal array of cylindrical projections of varying length is driven into the rods by a single linear actuator. The rods are displaced to conform to the patient's skin. This elegant device design permits the delivery of radiation to complex targets using readily available beta-emitting radionuclides, such as Yttrium-90 (Y-90) or Strontium-90 (Sr-90).A working prototype of a novel CSBT device was built using 3D-printing technology that provides a safe and economically attractive means of improving radiation delivery to complex treatment sites.ChmuraJenniferJ0000-0001-6662-202XBiomedical Engineering Department, University of Minnesota, Minneapolis, MN, USA. jennchm@gmail.com.Medical Devices Center, University of Minnesota, Minneapolis, MN, USA. jennchm@gmail.com.ErdmanArthurAMedical Devices Center, University of Minnesota, Minneapolis, MN, USA.EhlerEricEDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.LawrenceJessicaJDepartment of Veterinary Clinical Sciences, University of Minnesota, St Paul, MN, USA.WilkeChristopher TCTDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.RogersBrentBDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.FerreiraClaraCDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.engJournal Article20190722