AI Article Synopsis
- Epilepsy is a long-lasting neurological disorder that can severely impact quality of life and is particularly challenging to manage in the case of temporal lobe epilepsy (TLE), which is common among adults.
- This study aimed to identify specific volatile organic compounds (VOCs) in the urine of mice with TLE using advanced gas chromatography techniques, revealing 13 distinct VOCs that could serve as biomarkers for epilepsy.
- Further analysis grouped these VOCs and identified key compounds like methanethiol and 2-butanone as potential indicators, prompting future research to explore their relationship with metabolic processes and gut health in TLE.
Article Abstract
Epilepsy is a chronic neurological disorder affecting mammals, including humans. Uncontrolled epilepsy is associated with poor quality of life, accidents, and sudden death. In particular, temporal lobe epilepsy (TLE) is the most common type of pharmacoresistant epilepsy, which easily gets out of control in human adults. The aim of this study was to profile urinary volatile organic compounds (VOCs) in a mouse model of TLE using solid-phase microextraction (SPME) gas chromatography mass spectrometry (GC-MS). Thirteen urinary VOCs exhibited differential abundance between epileptic and control mice, and the corresponding areas under the receiver operating characteristic (ROC) curve were greater than 0.8. Principal component analysis (PCA) based on these 13 VOCs separated epileptic from sham operated-mice, suggesting that all these 13 VOCs are epilepsy biomarkers. Promax rotation and dendrogram analysis concordantly separated the 13 VOCs into three groups. Stepwise linear discriminant analysis extracted methanethiol; disulfide, dimethyl; and 2-butanone as predictors. Based on known metabolic systems, the results suggest that TLE induced by amygdala stimulation could affect both endogenous metabolites and the gut flora. Future work will elucidate the physiological meaning of the VOCs as end-products of metabolic networks and assess the impact of the metabolic background involved in development of TLE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646363 | PMC |
| http://dx.doi.org/10.1038/s41598-019-46373-8 | DOI Listing |
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