Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of and spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all spp. tested, including and coagulase-negative staphylococci (MIC, 0.5/1 μg/ml). Activity against spp. was variable, with , , and (MIC, 1/2 μg/ml) among the most susceptible.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761524 | PMC |
| http://dx.doi.org/10.1128/AAC.01078-19 | DOI Listing |
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