AI Article Synopsis
- - The 'Immunogenetics of Aging' project investigates how specific immunogenetic markers, particularly HLA and cytokine genes, relate to successful aging and longevity.
- - Recent findings from the 17th International HLA and Immunogenetics Workshop used Next Generation Sequencing to identify significant associations between certain HLA alleles and healthy aging in elderly individuals compared to younger controls.
- - The research suggests that specific HLA alleles and haplotypes may enhance disease resistance, indicating they could serve as valuable markers for understanding successful aging and longevity.
Article Abstract
The 'Immunogenetics of Aging' project is a component introduced in the 14th International HLA and Immunogenetics Workshop (IHIW) and developed further within subsequent workshops. The aim was to determine the relevance of immunogenetic markers, focusing on HLA, cytokine genes, and some innate immunity genes, for successful aging and an increased capacity to reach the extreme limits of life-span. Within the 17th IHIW we applied Next Generation Sequencing methods to refine further HLA associations at allele level in longevity, and to extend our knowledge to additional loci such as HLA-DQA1, HLA-DPB1 and HLA-DPA1. Analysis of relatively small number of healthy elderly and young controls from four populations showed that some HLA class I and class II alleles were significantly positively associated with healthy aging. Additionally we observed statistically significant differences in HLA allele distribution when the analysis was performed separately in elderly females and males compared to sex-matched young controls. Haplotypes, probably associated with better control of viral and malignant diseases were increased in the elderly sample. These preliminary NGS data could confirm our hypotheses that survival and longevity might be associated with selection of HLA alleles and haplotypes conferring disease resistance or susceptibility. Therefore HLA alleles and haplotypes could be informative immunogenetic markers for successful ageing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773488 | PMC |
| http://dx.doi.org/10.1016/j.humimm.2019.07.287 | DOI Listing |
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