New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus .

Three new -hydroxyl butenolides (-), a pair of new enantiomeric spiro-butenolides ( and ), a pair of enantiomeric cyclopentenones ( new and new natural), and six known compounds (-), were isolated from . Their structures were established by spectroscopic data and electronic circular dichroism (ECD) spectra. Two pairs of enantiomers [(+)/(-)- and (+)/(-)-] obtained from the reaction of with acetyl chloride (AcCl) confirmed that was a mixture of two pairs of enantiomers. In addition, the X-ray data confirmed that was also a racemate. The new metabolites (- were evaluated for their inhibitory activity against cancer and non-cancer cell lines. As a result, compound exhibited moderate cytotoxicity to HL60 and A549 with IC values of 6.5 and 8.9 µM, respectively, and weak potency to HL-7702 with IC values of 17.6 µM. Furthermore, compounds - were screened for their antimicrobial activity using the micro-broth dilution method. MIC values of 200 μg/mL were obtained for compounds and towards and , while compound exhibited a MIC of 50 μ/mL towards .