Contamination with the eight elements, Hg, As, Cr, Cu, Ni, Pb, Zn, and Cd, is a serious concern in Zhongshan, which is a typical light industrial city, China. 60 surface soil samples were collected to investigate the concentrations, spatial distribution, human health risk, and sources of these elements in the soils in Zhongshan. The concentrations of the eight elements were analyzed while using ordinary kriging analysis, pollution load index (PLI), potential ecological risk index (RI), human health risk, correlation analysis, and factor analysis. The mean concentrations of the tested elements, excluding Pb and As, were higher than the soil background values in the Pearl River Delta. The spatial distribution of the tested elements revealed a zonal distribution pattern and high values in several areas. The mean PLI and RI indicated slight and moderate risk levels. Health risk assessment demonstrates that both children and adults were more exposed to Cu than to Cr, As, and Cd. However, the associated carcinogenic risk is acceptable. Hg that originated from human activities; As, Cr, Cu, Ni, and Cd originated from industrial activities; and, Pb and Zn originated from transportation activities. Cd was the main pollutant in the study area and it was present at higher concentrations when compared with those of the other elements. Therefore, Zhongshan should encourage enterprises to conduct industrial transformation to control the ecological risk.
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http://dx.doi.org/10.3390/ijerph16142591 | DOI Listing |
Langmuir
January 2025
School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, Jiangsu 211189, P. R. China.
This study aims to improve the signal-to-noise ratio (SNR) of chemiluminescence immunoassay (CLIA) by increasing the amount of protein immobilized on the surface of the magnetic bead (MB). Proteins are macromolecules with three-dimensional structures, and merely increasing the density of functional groups on the two-dimensional surface of the MB cannot significantly enhance protein immobilization. Therefore, we grafted spatially extended functional polymer to not only increase the density of functional groups on the MB surface but also expand their distribution in three-dimensional space, ultimately increasing protein immobilization.
View Article and Find Full Text PDFTheranostics
January 2025
Neurooncology Unit, Instituto de Investigación Biomédicas I+12, Hospital Universitario 12 de Octubre, Madrid 28041, Spain.
Glioblastoma IDH wild type (GBM IDH wt) has a poor prognosis and a strongly associated with inflammatory processes. Inflammatory molecules generate positive feedback with tumor cells fueling tumor growth as well as recruitment of immune cells that promote aggressiveness. Although the role of many inflammatory molecules is well known, there are many macromolecules, such as the S100A proteins, whose role is only now beginning to be established.
View Article and Find Full Text PDFFront Public Health
January 2025
Department of Statistics, College of Science, Aksum University, Aksum, Ethiopia.
Background: The process of childbirth involves significant risks, particularly when certain high-risk fertility behaviors (HRFBs) are observed. HRFB of birth includes maternal age below 18 years or above 34 years at the time of childbirth, having a child born after a short birth interval (24 months), and having a high parity (more than three children). The majority of child stunting cases were linked to high-risk reproductive practices.
View Article and Find Full Text PDFJ Neurosci Res
January 2025
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Evidence suggests that hippocampal (HPC) disruption following learning produces retrograde amnesia on a range of tasks. Many of these tasks do not require HPC function in the anterograde direction suggesting that, in the intact brain, the HPC is actively involved during all forms of learning. However, prior work has also demonstrated double dissociations of HPC and amygdala function, which is inconsistent with this view.
View Article and Find Full Text PDFMagn Reson Chem
January 2025
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russia.
The complete H and C NMR assignments of a trimeric vindoline together with its individual components, dimeric vindolicine and monomeric vindoline, are performed based on a thorough analysis of the ROESY, COSY, HSQC, and HMBC spectra in combination with the state-of-the-art quantum-chemical calculations. A spatial structure of vindoline trimer is determined by means of computational conformational analysis in combination with the probability distribution map of its basic conformers. On the example of monoterpene indole alkaloid, the trimer vindoline, the present study reveals the power of modern computational NMR to perform identification and stereochemical studies of large natural compounds with some limitations, which may arise in the quantum chemical computing workflow.
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