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Objectives: The pairing of immunotherapy and radiotherapy in the treatment of locally advanced nonsmall cell lung cancer (NSCLC) has shown promise. By combining radiotherapy with immunotherapy, the synergistic effects of these modalities not only bolster antitumor efficacy but also exacerbate lung injury. Consequently, developing a model capable of accurately predicting radiotherapy- and immunotherapy-related pneumonitis in lung cancer patients is a pressing need.
View Article and Find Full Text PDFCurcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy.
Sci Rep
January 2025
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
Previous research indicates that Transforming growth factor beta-3 (TGFβ3) expression levels correlate with breast cancer metastasis, and elevated TGFβ3 levels have been linked with poor overall survival in breast cancer patients. The study used computational methods to examine curcumin's effects on TGFβ3, a chemical with antiviral and anticancer characteristics. The curcumin has low Molecular Weight 368.
View Article and Find Full Text PDFImpact of mandibular overdentures on maxillary resorption and its association with masticatory function: A prospective longitudinal study with 3 years of follow-up.
Arch Oral Biol
January 2025
Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.
Objective: This longitudinal clinical study monitored annually the maxillary and mandibular bone remodeling and masticatory function in complete denture (CD) wearers rehabilitated with implant-retained mandibular overdentures (MO) over three years and combined radiographic and masticatory function data to assess the correlation between bone remodeling and masticatory function.
Design: Thirty-nine MO wearers were monitored annually to assess changes in: i) residual ridge in the anterior and posterior maxillary region; ii) posterior height and posterior area index (PAI) in the mandible; and iii) masticatory function. Bone remodeling was measured through linear and angular measurements using panoramic radiographs.
Mechanically Resilient and Highly Efficient Flexible Perovskite Solar Cells with Octylammonium Acetate for Surface Adhesion and Stress Relief.
ACS Nano
January 2025
State Key Laboratory of Wide-Bandgap Semiconductor Devices and Integrated Technology, Faculty of Integrated Circuit, Xidian University, 710071 Xi'an, China.
Flexible perovskite solar cells (FPSCs) have advanced significantly because of their excellent power-per-weight performance and affordable manufacturing costs. The unsatisfactory efficiency and mechanical stability of FPSCs are bottleneck challenges that limit their application. Here, we explore the use of octylammonium acetate (OAAc) with a long, intrinsic, flexible molecular chain on perovskite films for surface adhesion and mechanical releasing.
View Article and Find Full Text PDFThe Efficacy of 3 Bleaching Methods on Stained Polymer-Based CAD/CAM Materials.
Int Dent J
January 2025
Biomaterials Science, Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester, UK.
Introduction And Aims: This study aimed to investigate the efficacy of 3 bleaching methods on stained polymer-based CAD/CAM blocks in terms of surface roughness, hardness stability, discolouration reduction and susceptibility to re-staining following bleaching.
Methods: Two-mm-thick slabs (N = 128) were prepared from CeraSmart (CS), Grandio Blocs (GB), Vita Enamic (VE), and direct resin composite GrandioSO (RC). Coffee-stained specimens (n = 8) were subdivided into bleaching (BL) groups: in-office bleaching (OB), home bleaching (HB), whitening mouthwash (MW), and a control group with 14-day storage in water (CL).
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