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Cross-Sectional Analyses to Assess the Clinical Safety and Effectiveness of Bisoprolol in Patients With Non-obstructive Coronary Artery Disease Who Underwent Percutaneous Coronary Intervention: A Post-hoc Analysis.
Cureus
December 2024
Medical Strategic Affairs, Torrent Pharmaceuticals Ltd., Ahmedabad, IND.
Introduction: Elevated central aortic pressure, cardiac output and peripheral vascular resistance contribute to high morbidity in relation to end organ dysfunction in obstructive and non-obstructive coronary artery disease (NOCAD) cases despite revascularization. Bisoprolol preempts further progression of left ventricular dysfunction in such cases due to anti-ischemic and anti-hypertensive effects, further extending its evaluation in local Indian settings.
Methods: Post-hoc analyses of NOCAD patients with epicardial stenosis (N=378, 30 to 70% stenosis) from cross-sectional analyses conducted across eighty centers in India.
Unmet medical needs and influencing factors among Korean police officers: a cross-sectional survey.
BMJ Open
August 2024
Health Administration, Dongseo University, Busan, Republic of Korea
Objectives: South Korea grapples with a disproportionately high incidence of unmet medical needs, a concern that is particularly acute among police officers, who are exposed to significant occupational risks. Given the pivotal role of police officers in upholding democratic values and public safety, their well-being holds critical societal implications. This study aims to determine the incidence of unmet medical needs among police officers and identify the influencing factors.
View Article and Find Full Text PDFEvaluation of psychosocial risks affecting academician using the sine trigonometric pythagorean fuzzy (ST-PFN) DEMATEL method.
Work
July 2024
Faculty of Engineering, Marmara University, Istanbul, Türkiye.
Background: In the realm of academia, psychosocial risk factors play a pivotal role, exerting considerable influence on the well-being and performance of scholars. Factors such as excessive workloads, unrelenting performance expectations, time constraints, and competitive atmospheres can detrimentally affect their health and overall quality of life. Moreover, issues like social isolation, work-life imbalance, and academic anxiety further compound these challenges, impeding academic progress and success.
View Article and Find Full Text PDFOnabotulinumtoxina in the Prevention of Migraine in Pediatric Population: A Systematic Review.
Toxins (Basel)
June 2024
Department of Neurology, Tallaght University Hospital, D24 NR0A Dublin, Ireland.
Migraine is a leading cause of disability worldwide, yet it remains underrecognized and undertreated, especially in the pediatric and adolescent population. Chronic migraine occurs approximately in 1% of children and adolescents requiring preventive treatment. Topiramate is the only FDA-approved preventative treatment for children older than 12 years of age, but there is conflicting evidence regarding its efficacy.
View Article and Find Full Text PDFThe Role of the Medial Prefrontal Cortex in Spatial Margin of Safety Calculations.
J Neurosci
August 2024
Department of Humanities and Social Sciences and Computation, California Institute of Technology, Pasadena, California 91125
Naturalistic observations show that animals pre-empt danger by moving to locations that increase their success in avoiding future threats. To test this in humans, we created a spatial margin of safety (MOS) decision task that quantifies pre-emptive avoidance by measuring the distance subjects place themselves to safety when facing different threats whose attack locations vary in predictability. Behavioral results show that human participants place themselves closer to safe locations when facing threats that attack in spatial locations with more outliers.
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