The adaptive changes elicited in visuomotor adaptation experiments are usually well explained at group level by two-rate models (Smith et al., 2006), but parameters fitted to individuals show considerable variance. Data cleaning can mitigate this problem, but the assumption of smoothness can be problematic due to fast adaptive changes with discontinuous derivatives. In this paper, we collected time-series data from an experimental paradigm involving repeated training and investigated the effect of various cleaning methods, including an autoencoder network (AE), on the parameter estimation. We compared changes in the fitted parameters across different methods and across training repetitions. The results suggest that AE performed best overall, without introducing an underestimation bias on b like moving average or piecewise polynomials, and that it reduced the within-subject variance overall and especially that of the fast retention rate a by >50%.
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http://dx.doi.org/10.1016/bs.pbr.2019.04.035 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125.
The diversity and heterogeneity of biomarkers has made the development of general methods for single-step quantification of analytes difficult. For individual biomarkers, electrochemical methods that detect a conformational change in an affinity binder upon analyte binding have shown promise. However, because the conformational change must operate within a nanometer-scale working distance, an entirely new sensor, with a unique conformational change, must be developed for each analyte.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Ewing Marion Kauffman Foundation, Kansas City, MO 64110.
Research that better aligns policy, practice, and research communities is gaining momentum around the world. This includes engaged research strategies that bring partners, and their diverse perspectives and kinds of knowledge, together to shape research agendas with on-the-ground-needs and to create dynamic problem-solving processes. These approaches aim to generate more equitable and effective solutions to societal challenges.
View Article and Find Full Text PDFJMIR Res Protoc
January 2025
College of Medicine and Public Health, Flinders University, Bedford Park, Australia.
Background: There is limited evidence of high-quality, accessible, culturally safe, and effective digital health interventions for Indigenous mothers and babies. Like any other intervention, the feasibility and efficacy of digital health interventions depend on how well they are co-designed with Indigenous communities and their adaptability to intracultural diversity.
Objective: This study aims to adapt an existing co-designed mobile health (mHealth) intervention app with health professionals and Aboriginal and/or Torres Strait Islander mothers living in South Australia.
PLoS One
January 2025
Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Preeclampsia is characterized by insufficient invasion of extravillous trophoblasts and is a consequence of failed adaption of extravillous trophoblasts to changes in the intrauterine environment developing embryo. Specific miRNAs are implicated in the development of preeclampsia (PE). miR-455-5p is present at low levels in PE but its role is not known.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Philosophy, Philosophy of Science and the Study of Religion, Ludwig Maximilian University of Munich, München, Germany.
Many visualisations used in the climate communication field aim to present the scientific models of climate change to the public. However, relatively little research has been conducted on how such data are visually processed, particularly from a behavioural science perspective. This study examines trends in visual attention to climate change predictions in world maps using mobile eye-tracking while participants engage with the visualisations.
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