AI Article Synopsis
- Muscimol, the primary compound in Amanita muscaria, has been shown to reduce essential tremor without affecting speech or coordination.
- Several studies have highlighted muscimol's potential benefits for Parkinson's patients, particularly its antioxidant properties and free radical scavenging abilities.
- Research on a standardized A. muscaria extract showed significant neuroprotective effects in various brain models, but it did not inhibit the hMAOB enzyme.
Article Abstract
Muscimol is the main compound found in Amanita muscaria. Several studies have proven that muscimol has suppressive effects on essential tremor, without impairing speech and coordination. The effects of muscimol in Parkinson-affected patients is also described in a number of studies. These studies describe the free radical scavenging and antioxidant activity of the mushroom extract. We have evaluated the possible neuroprotective effects of a standardized extract from A. muscaria, containing high amounts of muscimol, on different models of neurotoxicity in rat brain microsomes, mitochondria, synaptosomes as well as on neuroblastoma cell line SH-SY5Y. The possible inhibitory effect on human recombinant monoaminoxidase-B (hMAOB) enzyme was also studied. The extract revealed statistically significant neuroprotective effects on the in vitro neurotoxicity models and no inhibitory activity on hMAOB.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fct.2019.110687 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!