It is widely assumed that inositol trisphosphate (IP) and ryanodine (Ry) receptors share the same Ca pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP- and Ry-receptors are associated with two functionally distinct intracellular Ca stores, respectively. While the IP-sensitive Ca store refilling requires Orai2 channels, Ry-sensitive Ca store refilling involves voltage-gated Ca channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.
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| http://dx.doi.org/10.1038/s41467-019-11207-8 | DOI Listing |
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