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Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.
Theranostics
January 2025
Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China.
Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn/SA-PBA network crosslinked via multiple physicochemical interactions.
View Article and Find Full Text PDFMulti-Targeting Phytochemicals for Alzheimer's Disease.
Phytother Res
January 2025
Department of Pharmaceutical Sciences, Hemwati Nandan Bahuguna Garhwal University (A Central University), Srinagar, Uttarakhand, India.
Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate in neurons in the form of tangles. The pathophysiological pathway of AD consists of Aβ-amyloid peptides, tau proteins, and oxidative stress in neurons and increased neuro-inflammatory response. Food and Drug Administration in the United States has authorized various drugs for the effective treatment of AD, which include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, and aducanumab.
View Article and Find Full Text PDFEvaluation of the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic molar teeth with open apex on postoperative pain- randomized clinical trial.
Clin Oral Investig
January 2025
Department of Pedodontics, Faculty of Dentistry, Erciyes University, 38039, Kayseri, Türkiye.
Objectives: This study evaluates the effect of different irrigation solutions for postoperative pain in the regenerative endodontic treatments (RET) of necrotic teeth with open apex.
Materials And Methods: This study included necrotic, deeply carious lower molars of 42 patients. Access cavities of the teeth were opened and working lengths were measured at the first visit.
A clinical study showing the expression characteristics of cuproptosis markers in cases with Wilson disease.
Medicine (Baltimore)
November 2024
First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
This study investigates levels of cuproptosis markers in Wilson disease (WD) and their role in the occurrence and development of WD. We retrospectively collected clinical data from 76 patients with Leipzig score ≥ 4 hospitalized in the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2023 to September 2023. The participants were given copper chelators (sodium dimercaptosulphonate (20 mg·kg-1), 4 courses of treatment, 32 days).
View Article and Find Full Text PDFHigh efficiency adsorption of boron by sodium alginate/polyethyleneimine/polysiloxane composite aerogel.
Int J Biol Macromol
January 2025
School of Light Industry & Chemical Engineering, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:
In this work, a new biomass boron adsorbent of N-methyl-D-glucosamine embedded sodium alginate/polyethyleneimine/polysiloxane composite aerogel (SKPN) was reported. Relevant characterization proved that the aerogel exhibited 3D porous structure with plenty of hydroxyl and amino functional groups, which was beneficial to the diffusion of boron and the chelation between boron and SKPN. Various parameters affecting the adsorption performance including pH value, contact time initial concentration, temperature and reusability were investigated.
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