AI Article Synopsis
- Sonic Hedgehog (SHH) is a critical morphogen that influences cell identities and functions by creating gradients of Hedgehog activation during development.
- Despite its well-established role in developing organs, the function of SHH in maintaining and regenerating adult organs is not fully understood.
- This review focuses on SHH signaling in the adult lung, exploring its role in regeneration and maintenance, as well as how changes in this signaling pathway may lead to lung diseases.
Article Abstract
As a secreted morphogen, Sonic Hedgehog (SHH) determines differential cell fates, behaviors, and functions by forming a gradient of Hedgehog (Hh) activation along an axis of Hh-receptive cells during development. Despite clearly delineated roles for Hh during organ morphogenesis, whether Hh continues to regulate cell fate and behavior in the same fashion in adult organs is less understood. Adult organs, particularly barrier organs interfacing with the ambient environment, are exposed to insults that require renewal of cellular populations to maintain structural integrity. Understanding key aspects of Hh's ability to generate an organ could translate into conceptual understanding of Hh's ability to maintain organ homeostasis and stimulate regeneration. In this review, we will summarize the current knowledge about Hh signaling in regulating adult lung regeneration and maintenance, and discuss how alteration of Hh signaling contributes to adult lung diseases.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787692 | PMC |
| http://dx.doi.org/10.3390/jdb7030014 | DOI Listing |
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