The success of surgical treatment of maxillo-facial bone defects depends on bone regeneration ability. Bone volume can be restored by surgical implantation of various biomaterials, which have ability either to accomplish mechanically the function of bone or to produce the induction effect on bone regeneration process. Latest advancements in tissue engineering are enabling to find new materials with significantly less disadvantages than the currently used osteoplastic materials. Therefore, the aim of our experimental study was to evaluate the efficiency of decellularized bovine bone matrix for reconstruction of jaw bone defects during implantation in animal model. In control group mandibular bone defected has been modelled, while in experimental group in modelled defect has been placed implant and decellularized bone graft. Animals were under surveillance and then sacrificed. Reparative processes in tissues has been monitored by morphologic and radiographic evaluation. The results revealed that the presented bone matrix during dental implantation enables complete reparational regeneration of bone and ideal osseointegration of dental implant, ensures local realization of potential of osteoprogenitor cells, accelerates osteogenesis and decreases the time of healing, due to its osteoinductive and osteoconductive abilities So we can suggest that natural mineral bone matrix developed by us, will meet all the claims mentioned above and will be effective in clinical practice.
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