Age at Menarche and Risk of Respiratory Diseases.

Several studies have suggested a relationship between reproductive history and respiratory health. The present study explores the association between the age at menarche and the risk of respiratory diseases during early adulthood. The anthropometrical and questionnaire research was conducted among 1323 female university graduates. In a subsample of 152 non-allergic women spirometry tests were additionally performed. We found that the prevalence of allergic diseases, on average, was slightly higher among females having early menarche than in those with a later onset of menstruation; the difference failed to reach statistical significance. However, the risk of allergic rhinitis was significantly related with early menarche compared with average-time, taken as a reference, or late menarche (OR = 1.61 vs. OR = 1 (Ref.) vs. OR = 1.23, p = 0.020). The difference remained significant after adjusting for adiposity (p = 0.050) and socio-economic status (p = 0.001). There was no significant relationship between the age at menarche and the incidence of respiratory infections. We noticed a tendency for increased spirometry variables with increasing age at menarche. In conclusion, early menarche is a risk factor for allergic rhinitis in early adulthood.