Diabetic myonecrosis (DMN) is a rare microangiopathic disorder that can present as an acutely painful and swollen limb in patients with established diabetes mellitus. The condition can be diagnosed noninvasively with magnetic resonance imaging and resolves with analgesia, bed rest, and glycemic control. Due to a relative lack of awareness regarding the condition, avoidable interventions such as muscle biopsies and even surgery are sometimes pursued, which have been associated with prolonged recovery times. The majority of patients with DMN have diabetic nephropathy, yet this condition is not widely recognized in the nephrology community, resulting in delayed diagnosis and patients undergoing unnecessary and potentially harmful investigations. There is therefore a need for increased awareness of the condition among renal physicians. Here, we report the cases of two patients on hemodialysis who were ultimately diagnosed with DMN, along with a review of the literature.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637392 | PMC |
| http://dx.doi.org/10.5414/CNCS109626 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Statin-Induced Necrotizing Autoimmune Myopathy: Diagnosis and Treatment Approach.
JCEM Case Rep
December 2024
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN 55905, USA.
The widespread use of statins for cardiovascular diseases has unveiled a new subset of inflammatory myopathy, immune-mediated necrotizing myopathy (IMNM). We describe below an unusual case of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy. A 64-year-old male individual with type 2 diabetes, hyperlipidemia, and coronary artery disease presented with progressive proximal muscle weakness and pain for 3 months.
View Article and Find Full Text PDFDiabetic myonecrosis: A rare complication of long-standing diabetes mellitus.
Prim Care Diabetes
November 2024
Department of Orthopaedics, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:
Article Synopsis
- Diabetes mellitus is increasingly common globally, leading to various complications, including rarer ones like diabetic myonecrosis, which are not well-documented.
- The case involves a 49-year-old man with Type 2 diabetes who experienced sudden thigh pain and swelling; initial treatments did not resolve his symptoms, prompting further imaging studies.
- The case emphasizes the importance of recognizing diabetic myonecrosis early to avoid unnecessary procedures and highlights that while muscle biopsy is the best diagnostic method, MRI can provide sufficient evidence for diagnosis and management.
[Fatal course of a fulminant gas gangrene of the right hemithorax].
Unfallchirurgie (Heidelb)
January 2025
Klinik für Unfallchirurgie und Orthopädie, Universitätsklinikum Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.
Article Synopsis
- Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
- Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
- Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Diabetes Myonecrosis: A Debilitating Complication in an Indigenous Young Woman With Long Standing Type 1 Diabetes Mellitus.
Case Rep Endocrinol
September 2024
Department of Diabetes and Endocrinology Townsville University Hospital, Townsville, Australia.
Article Synopsis
- A 24-year-old Indigenous Australian woman with poorly controlled type 1 diabetes presented with swelling and pain in her thigh for three months.
- Tests revealed an ongoing inflammatory state, but infectious and autoimmune causes were ruled out.
- The case emphasizes diabetic myonecrosis as a rare but serious complication of diabetes, underscoring the importance of good blood sugar management to prevent such issues.
Diabetes-Associated Focal Myonecrosis: A Case Report and Literature Review.
Cureus
July 2024
Pathology, Thomas Jefferson University Hospital, Philadelphia, USA.
Diabetes-associated focal myonecrosis is a rare complication seen in individuals with long-standing uncontrolled diabetes, characterized by inflammation and necrosis of a single or group of muscles. The exact cause of this condition is not well understood, but it is believed to be due to focal muscle infarction secondary to arteriosclerosis and diabetic microangiopathy. Diagnosis is challenging and often requires clinical examination, lab investigations, imaging, and EMG.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!