AI Article Synopsis
- Thoracic aortic dissection (TAD) is a severe condition needing quick diagnosis and treatment, but current drug delivery systems are inadequate due to the disease's specific vascular challenges.
- Researchers have developed a multifunctional delivery nanosystem (TP-Gd/miRNA-ColIV) that combines several components for targeted therapy, early diagnosis, and monitoring of TAD.
- This new treatment significantly stabilizes aortic structures in mice models of TAD and allows for effective noninvasive imaging to track disease progression.
Article Abstract
Thoracic aortic dissection (TAD) is an aggressive vascular disease that requires early diagnosis and effective treatment. However, due to the particular vascular structure and narrowness of lesion location, there are no effective drug delivery systems for the therapy of TAD. Here, we report a multifunctional delivery nanosystem (TP-Gd/miRNA-ColIV) composed of gadolinium-chelated tannic acid (TA), low-toxic cationic PGEA (ethanolamine-aminated poly(glycidyl methacrylate)) and type IV collagen targeted peptide (ColIV) for targeted nucleic acid therapy, early diagnosis and noninvasive monitoring of TAD. Such targeted therapy with miR-145 exhibits impressive performances in stabilizing the vascular structures and preventing the deterioration of TAD. After the treatment with TP-Gd/miR-145-ColIV, nearly no dissection occurs in the thoracic aortic arches of the mice with TAD model. Moreover, TP-Gd/miRNA-ColIV also demonstrates good magnetic resonance imaging (MRI) ability and can be used to noninvasively monitor the development conditions of TAD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639375 | PMC |
| http://dx.doi.org/10.1038/s41467-019-11068-1 | DOI Listing |
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