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| http://dx.doi.org/10.1073/pnas.1910420116 | DOI Listing |
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An analytical study of active earth pressure in cohesive soil considering interlayer shear stress.
PLoS One
January 2025
Ltd Project Construction Management Company, Jiangxi Provincial Communications Investment Group Co., Nanchang, China.
The impact of interlayer shear stress on the distribution of earth pressure in cohesive soil is notable, but currently, there lacks a comprehensive theory that integrates this factor in the calculation of active earth pressure. Drawing from the Mohr stress circle specific to clay soils, a formula to calculate interlayer shear stress has been derived. Moreover, a robust model has been formulated to compute the active earth pressure in clay soils, incorporating elements such as interlayer shear stress, effects of displacement, soil arching, and the morphology of the sliding surface.
View Article and Find Full Text PDFTrauma exposure and posttraumatic stress symptoms: Associations with self-reported dietary and exercise changes.
Psychol Trauma
January 2025
Department of Psychological Sciences, University of Missouri-St. Louis.
Objective: Exposure to trauma and subsequent posttraumatic stress symptoms (PTSS) increase the risk of poor physical health outcomes. Yet, the nuances of the paths from trauma to poor health are largely theoretical, and research regarding how trauma types relate to specific trauma-related changes to diet and exercise is needed. The present study examined the associations between noninterpersonal and interpersonal trauma and PTSS with several novel dietary and exercise changes (i.
View Article and Find Full Text PDFStress Management Program for Scanxiety in People With Advanced Lung Cancer: Intervention Adaptation and Stakeholder Feedback.
Psychooncology
January 2025
Cancer Prevention Precision Control Institute, Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Background: Although scanxiety is common and impactful for people with advanced lung cancer, few interventions address this psychosocial concern.
Aims: To create a stress management program for scanxiety.
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Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures.
J Vis Exp
December 2024
The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Faculty of Health and Medical Sciences, School of Medicine, Tel Aviv University;
Cerebellar Purkinje cells (PCs) exhibit a unique interplay of high metabolic rates, specific chromatin architecture, and extensive transcriptional activity, making them particularly vulnerable to DNA damage. This necessitates an efficient DNA damage response (DDR) to prevent cerebellar degeneration, often initiated by PC dysfunction or loss. A notable example is the genome instability syndrome, ataxia-telangiectasia (A-T), marked by progressive PC depletion and cerebellar deterioration.
View Article and Find Full Text PDFCirculating autophagy regulator Rubicon is linked to increased myocardial infarction risk.
J Mol Cell Cardiol Plus
March 2025
Center for Clinical Investigation (CIC1436)/CARDIOMET, Rangueil University Hospital, Toulouse, France.
Background: The identification of new biomarkers that improve existing cardiovascular risk prediction models for acute coronary syndrome is essential for accurately identifying high-risk patients and refining treatment strategies. Autophagy, a vital cellular degradation mechanism, is important for maintaining cardiac health. Dysregulation of autophagy has been described in cardiovascular conditions such as myocardial ischemia-reperfusion injury, a key factor in myocardial infarction (MI).
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