https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=31320490&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 313204902020031620200316
1525-14382972019SepInternational journal of gynecological cancer : official journal of the International Gynecological Cancer SocietyInt J Gynecol CancerTriple tracer (blue dye, indocyanine green, and Tc99) compared to double tracer (indocyanine green and Tc99) for sentinel lymph node detection in endometrial cancer: a prospective study with random assignment.112111251121-112510.1136/ijgc-2019-000387Sentinel lymph node (SLN) mapping is increasingly being used in the treatment of apparent early-stage endometrial cancer. The aim of this study was to evaluate whether three tracers (blue dye, indocyanine green (ICG), and technetium-99 (Tc99)) performed better than two (ICG and Tc99).Prospective study of all consecutive patients (n=163) diagnosed with clinical early-stage endometrial cancer from 2015 to 2017. All patients were randomly assigned to receive a mixture of ICG and Tc99 with or without blue dye. Subgroup analysis for detection rates was performed for each group (double versus triple tracer).One hundred and fifty-seven patients met the inclusion criteria. Eighty patients received ICG and Tc99 with unilateral and bilateral SLN detection rates of 97.5% and 81.3%, respectively. Seventy-seven patients received all three tracers with unilateral and bilateral detection rates of 93.5% and 80.5%, respectively. Only one patient in the triple tracer group was detected by blue dye alone. No significant differences were noticed in unilateral or bilateral detection rates between the two groups, nor in the detection of lymph node metastasis.The addition of blue dye to ICG and Tc99 did not demonstrate any improvement in SLN detection.© IGCS and ESGO 2019. No commercial re-use. See rights and permissions. Published by BMJ.KessousRoyRDepartment of Obstetrics and Gynecology; Faculty of Health Sciences, Soroka University Medical Center; Ben-Gurion University of the Negev, Beer-Sheva, Israel.HowJeffreyJDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.AbitbolJeremieJDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.PuzhakkalSanamSDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.KoganLironLDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.YasmeenAmberADivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.SalvadorShannonSDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.GotliebWalter HWHDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada walter.gotlieb@mcgill.ca.LauSusieSDivision of Gynecologic Oncology, Jewish General Hospital - McGill University Faculty of Medicine, Montreal, Québec, Canada.engJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't20190717
EnglandInt J Gynecol Cancer91116261048-891X0Coloring Agents0Rosaniline Dyes0Technetium-997440-26-8TechnetiumFH1929ICITsulfan blueIX6J1063HVIndocyanine GreenIMAgedColoring AgentsEndometrial NeoplasmspathologyFemaleHumansIndocyanine GreenLymphatic MetastasisMiddle AgedProspective StudiesRosaniline DyesSentinel Lymph NodepathologySentinel Lymph Node BiopsymethodsTechnetiumblue dyeendometrial cancerindocyanine greensentinel lymph node mappingtechnetiumCompeting interests: None declared.
20192262019629201972201972060202031760201972060ppublish3132049010.1136/ijgc-2019-000387ijgc-2019-000387