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The Antiviral Effect of Berdazimer Sodium on Molluscum Contagiosum Virus Using a Novel In Vitro Methodology.
Viruses
November 2023
Novan, Durham, NC 27703, USA.
Article Synopsis
- Molluscum contagiosum (MC) is a common skin infection in children caused by the highly contagious molluscum contagiosum poxvirus (MCV), with limited treatment options available.
- Researchers are investigating berdazimer sodium, a new topical treatment, to assess its antiviral properties against poxviruses using vaccinia virus as a model since MCV can't be studied directly in the lab.
- The study shows that berdazimer sodium not only reduces virus replication but also interferes with early gene expression in MCV-infected cells, offering a possible explanation for its effectiveness in treating MC.
NVN1000, a novel nitric oxide-releasing compound, inhibits HPV-18 virus production by interfering with E6 and E7 oncoprotein functions.
Antiviral Res
October 2019
Biochemistry and Molecular Genetics, University of Alabama at Birmingham, AL, 35294-0005, USA.
Article Synopsis
- Tinea pedis, or athlete's foot, is a common fungal skin infection treated topically, with SB208 being a new treatment that releases nitric oxide to combat the infection.
- A phase 2 trial showed that patients treated with SB208 had a higher rate of negative fungal cultures after 14 days compared to those using a placebo, particularly with the 4% dose.
- At 42 days, SB208 also demonstrated greater mycological and clinical cures, and it was generally safe with no serious side effects reported.
Nitric Oxide-Releasing Macromolecule Exhibits Broad-Spectrum Antifungal Activity and Utility as a Topical Treatment for Superficial Fungal Infections.
Antimicrob Agents Chemother
July 2018
Novan, Inc., Morrisville, North Carolina, USA.
Cutaneous and superficial fungal infections affecting the skin, nails, and hair of humans are caused primarily by dermatophytes of the genera and or by yeasts of the genera and Onychomycosis is a common fungal infection of the nail that frequently coexists with tinea pedis, the most prevalent mycotic skin infection. Efficacy rates for current topical onychomycosis therapies are hampered by low drug penetration across the nail plate, which is theoretically obviated with nitric oxide (NO)-based topical therapies. The Nitricil technology platform is comprised of polysiloxane-based macromolecules that stably release therapeutic levels of NO.
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