The chromatographic separation of the components of the acetone extract of fruits yielded five new phenolic compounds including two chalcones, and , a functionalized phloroglucinol, , two flavanones, and , and six known compounds. The structures of - were confirmed by NMR and mass analyses. Racemic compounds and were separated by chiral-phase HPLC, and the absolute configuration of (+)- was confirmed by X-ray diffraction studies and ECD spectroscopic data. The configurations of the enantiomers of were defined by comparison of its ECD data with those of (+)-. Compounds and exhibited significant antibacterial activities, with MIC values ranging from 3.8 to 15.5 μM.
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http://dx.doi.org/10.1021/acs.jnatprod.9b00182 | DOI Listing |
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