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Recent Advance in Sensitive Detection of Demethylase FTO.
Chembiochem
December 2024
China Three Gorges University, College of Biological and Pharmaceutical Sciences, No. 8, Daxue Road, 443002, Yichang, CHINA.
Methylation modification is a critical regulatory mechanism in epigenetics, playing a significant role in various biological processes. N6-methyladenosine (m6A) is the most prevalent modification found in RNA. This modification is dynamic and reversible, regulated by methyltransferases and demethylases.
View Article and Find Full Text PDF[Quick decisionmaking for acute pulmonary embolism patients].
Ned Tijdschr Geneeskd
December 2024
Leids Universitair Medisch Centrum, Leiden. Afd. Trombose & Hemostase.
Treatment options for patients with severe pulmonary embolism (PE) have increased substantially over the past decade. Although systemic thrombolysis is still the reperfusion therapy of choice for hemodynamically unstable PE patients, several new catheter guided reperfusion therapies have emerged as possibly safer alternatives. These therapies are increasingly implemented in clinical practice even though their efficacy and safety are yet to be proven by clinical outcome studies.
View Article and Find Full Text PDFA high-entropy engineering on sustainable anionic redox Mn-based cathode with retardant stress for high-rate sodium-ion batteries.
Angew Chem Int Ed Engl
December 2024
Beijing University of Technology, Materials Science and Technology, Pingleyuan 100#, Chaoyang District, 100124, Beijing, CHINA.
Manganese-based (Mn-based) layered oxides have emerged as competitive cathode materials for sodium-ion batteries (SIBs), primarily due to their high energy density, cost-effectiveness, and potential for mass production. However, these materials often suffer from irreversible oxygen redox reactions, significant phase transitions, and microcrack formation, which lead to considerable internal stress and degradation of electrochemical performance. This study introduces a high-entropy engineering strategy for P2-type Mn-based layered oxide cathodes (HE-NMCO), wherein a multi-ingredient cocktail effect strengthens the lattice framework by modulating the local environmental chemistry.
View Article and Find Full Text PDFMachine learning in personalized laryngeal cancer management: insights into clinical characteristics, therapeutic options, and survival predictions.
Eur Arch Otorhinolaryngol
December 2024
King Hussein Cancer Center, Medical Oncology Department, Amman, Jordan.
Purpose: Over the last 40 years, there has been an unusual trend where, even though there are more varied treatments, survival rates have not improved much. Our study used survival analysis and machine learning (ML) to investigate this odd situation and to improve prediction methods for treating non-metastatic LSCC.
Methods: The surveillance, epidemiology and end results (SEER) database provided the data used for this study's analysis.
Topotactic Transformation in Fe3O4 Induces Spontaneous Growth of Compositionally Diverse Nanostructures.
Angew Chem Int Ed Engl
December 2024
Nanjing University, Biomedical Engineering, 22 Hankou Rd, 210093, Nanjing, CHINA.
Topotactic transformation is an emerging strategy for synthesizing materials with exotic functional properties. In this report, instead of producing new crystals with related structures, we exploited the topotactic transformation phenomenon to spontaneously produce compositionally diverse nanostructures on the transforming substrate. The surface of magnetite nanoparticles (Fe3O4 NPs) is topotactically transformed into maghemite (γ-Fe2O3).
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