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Analgesic Overdose in Patients With Dental Pain. A Cross-Sectional Study in Two Dental Emergency Clinics.

Basic Clin Pharmacol Toxicol

February 2025

Department of Odontology, Section of Oral Biology and Immunopathology, University of Copenhagen, Copenhagen, Denmark.

Dental pain is common, and many patients use analgesics to alleviate the pain. Analgesics are readily accessible, and overdosing may lead to severe complications. This study explores the extent of analgesic overdosing in patients with dental pain.

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Introduction: Since late 2019, SARS-CoV-2 has infected over 767 million people worldwide with over one million deaths in the United States alone. One risk factor identified for possible worse outcomes from the virus is medication-induced immune suppression. Some opioids have been associated with immunomodulatory effects.

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Objectives: This study evaluates the prevalence and correlates of opioid agonist therapy (OAT) discontinuation across British Columbia (BC), using a sample of individuals who used substances and accessed harm reduction sites.

Design: This study uses data from the 2019 cross-sectional Harm Reduction Client Survey (HRCS).

Setting: The 2019 survey was administered from October to December at 22 harm reduction supply distribution sites across the 5 Regional Health Authorities of BC.

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Aim: To evaluate the efficacy of flexible ureteroscopic lithotripsy (FURL) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of ureteral calculi based on decision tree model.

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